| 心包肽类激素免疫组织化学及免疫电镜的研究 |
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| 引用本文： | 温绍君 张维君. 心包肽类激素免疫组织化学及免疫电镜的研究[J]. 首都医科大学学报, 1993, 14(3): 192-195 |
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| 作者姓名： | 温绍君 张维君 |
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| 作者单位： | 首都医学院宣武医院，首都医学院宣武医院，首都医学院宣武医院，首都医学院宣武医院，首都医学院附属北京安贞医院，首都医学院附属北京安贞医院，首都医学院附属北京安贞医院，首都医学院附属北京安贞医院，中国医学科学院基础医学研究所，中国医学科学院基础医学研究所 |
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| 摘 要： | 采用免疫组织化学、免疫电子显微镜及高效液相结合放射免疫学方法,研究人和 Wistar 大鼠心包,结果表明:心包组织中存在 ANF 和 AngⅡ样物质。在采用兔抗 ANF 为抗体时,心包组织的间皮细胞存在明显的金粒子标记颗粒,间皮细胞是主要的内分泌细胞。心包组织存在 Ang Ⅱ和3种分子形式ANF.本研究提示.心包除已知功能外,尚存在重要的内分泌功能.
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| 关 键 词： | 局部肾素血管紧张素系统 血管紧张素Ⅱ 心钠素 心包 免疫组织化学 免疫电镜 |
| 收稿时间： | 1992-04-15 |
Study on Peptide Hormones in the Pericardiums with Immunohistochemistry and Immunoelectronmicroscopy |
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| Wen Shaojun He Shida Lu Dehong Wang Jiarui Xuanwu Hospital,Capital Institute of MedicineZhang Weijun Hu Xudong Chen Baotian Zhao Yingxin Beijing Anzhen Hospital,Capital Institute of MedicineGong Yihong Luo Liqun Institute of Basic Medical,Chinese Academy of Medical Sciences. Study on Peptide Hormones in the Pericardiums with Immunohistochemistry and Immunoelectronmicroscopy[J]. Journal of Capital Medical University, 1993, 14(3): 192-195 |
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| Authors: | Wen Shaojun He Shida Lu Dehong Wang Jiarui Xuanwu Hospital Capital Institute of MedicineZhang Weijun Hu Xudong Chen Baotian Zhao Yingxin Beijing Anzhen Hospital Capital Institute of MedicineGong Yihong Luo Liqun Institute of Basic Medical Chinese Academy of Medical Sciences |
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| Affiliation: | 1. Xuanwu Hospital, Capital Institute of Medicine;2. Beijing Anzhen Hospital, Capital Institute of Medicine;3. Institute of Basic Medical, Chinese Acade pf Medical Sciences |
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| Abstract: | With immunohistochemistry,immunoelectronmicroscopy and high pressure liquid chro-matography-radio-immunoassay methods,We have studied the pericardium of humans and Wistar rats.The presence of angiotensin Ⅱ and atrial natriuretic factor like materials(ANF-LMs)was demonestrated in the pericardium.Gold particles were found in some granular ar-eas of the cytoplasm of mesothelial cells with antihuman-ANF.Mesothelial cells appeared the principal endocrinesecreting ones.There were Ang Ⅱ and three molecular forms of ANF in the pericardium.It was suggested that beyond the known functions,there were important endocrine functions related to pericardium. |
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| Keywords: | local renin-angiotensin system angiotensin Ⅱ atrial natriuretic factor pericardium immunohistochemistry immunoelectronmicroscopy |
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