| 叶酸修饰乳酸-羟基乙酸共聚物纳米粒的制备及性能表征 |
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| 引用本文： | 凌 友,黄岳山,梁常艳,李小毛.叶酸修饰乳酸-羟基乙酸共聚物纳米粒的制备及性能表征[J].中国神经再生研究,2008,12(36):7049-7052. |
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| 作者姓名： | 凌 友 黄岳山 梁常艳 李小毛 |
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| 作者单位： | 华南理工大学生物科学与工程学院;华南理工大学生物科学与工程学院;中山大学附属第三医院妇产科;中山大学附属第三医院妇产科 |
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| 基金项目： | 广东省科技计划项目基金资助（2007B030502014）：叶酸受体介导的PLGA/TPGS纳米紫杉醇靶向抗子宫内膜癌的研究 |
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| 摘 要： | 以聚乙二醇二氨为偶联剂，通过叶酸活性酯和聚合物端基活性酯与聚乙二醇二氨反应，制得叶酸修饰的大分子，再通过乳化法合成载紫杉醇纳米粒，制备叶酸修饰的乳酸-羟基乙酸共聚物纳米粒子。紫外光谱、红外光谱、核磁光谱显示叶酸成功连接在高聚物分子上。所制得的纳米粒粒径（276±12）nm，扫描电镜观察其形态为规整的球形。该方法可成功制备叶酸修饰的乳酸-羟基乙酸共聚物载药纳米粒。
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| 关 键 词： | 叶酸 乳酸-羟基乙酸共聚物 纳米粒 修饰 生物材料 |
Preparation and characterization of folate-mediated poly (lactic-co-glycolic) acid nanoparticles |
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| Ling You,Huang Yue-shan,Liang Chang-yan and Li Xiao-mao.Preparation and characterization of folate-mediated poly (lactic-co-glycolic) acid nanoparticles[J].Neural Regeneration Research,2008,12(36):7049-7052. |
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| Authors: | Ling You Huang Yue-shan Liang Chang-yan and Li Xiao-mao |
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| Institution: | College of Bioscience and Bioengineering, South China University of Technology;College of Bioscience and Bioengineering, South China University of Technology;Department of Gynaecology and Obstetrics, Third Affiliated Hospital, Sun Yat-sen University;Department of Gynaecology and Obstetrics, Third Affiliated Hospital, Sun Yat-sen University |
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| Abstract: | Folate-mediated poly (lactic-co-glycolic) acid was prepared by the reaction of the activated folate ester and activated polymer with the amine group on the poly (ethylene glycol)-bis-amine. Folate-mediated poly (lactic-co-glycolic) acid nanoparticles were then formulated with the emulsion-solvent evaporation method. Results of ultraviolet spectra (UV) spectrum test, infrared (IR) spectrum test and nuclear magnetic resonance (H1NMR) test that the folate was conjugated successfully with polymer. The average diameter of nanoparticles was (276±12) nm and the Folate-mediated poly (lactic-co-glycolic) acid nanoparticles were spherical in shape as shown under the scanning election microscope. Folate-mediated poly (lactic-co-glycolic) acid nanoparticles for loading paclitaxel could be prepared successfully with the method. |
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