左炔诺孕酮宫内缓释系统治疗子宫内膜异位症的安全性研究

目的：观察和评估子宫内膜异位症患者应用左炔诺孕酮宫内缓释系统（1evonorgestrel-releasing intrauterinesystem，LNG—IUS）的安全性。方法：共59例子宫内膜异位患者纳入研究。将LNG—IUS放置在患者子宫腔内，LNG—IUS放置前与放置后6个月及12个月对患者的痤疮、面部色素沉着、月经前乳房胀痛、体重及生活质量进行评分及比较，并观察LNG—IUS不良反应发生情况。结果：LNG．IUS放置前和放置后6个月痤疮评分分别为1．00（0．00，3．00）和0．00（0．00，2．00），差异无统计学意义（P〉0．05），而放置后12个月痤疮评分为0．00（0．00，1．00），差异有统计学意义（P〈0．01）。放置前和放置后6个月及12个月的面部色素沉着评分均为1．00（0．00，1．00），差异无统计学意义（均P〉0．05）。放置前和放置后6个月及12个月的月经前乳房胀痛评分分别为2．20（0．00，4．00），1．50（0．00，4．00）及1．00（0．00，3．00），差异均有统计学意义（P〈0．05，P〈0．01）。放置前和放置后6个月及12个月的体重分别为59．00（55．00，64．00）b，59．50（55．00，64．00）kg及59．00（54．00，64．00）妇，差异均无统计学意义（均P〉0．05）。放置前和放置后6个月及12个月的生活质量评分差异均有统计学意义（均P〈0．01）。放置前和放置后6个月及12个月月经间期出血分别为4例（6．78％），16例（27．12％）及14例（23．73％）。其他不良反应有脱发（1例）和全身肿胀感（2例）。结论：LNG—IUS是一种治疗子宫内膜异位症的安全疗法。

Studies on safety of levonorgestrel-releasing intrauterine system in treatment of endometriosis

Objective： To observe and evaluate the safety of levonorgestrel-releasing intrauterine system （LNG-IUS） in the treatment of endometriosis. Methods： A total of 59 patients with endometriosis were studied. The LNG-IUS was inserted into the uterine cavity. The acne, facial pigmentation, premenstrual mammary swelling, the body weight, and quality of life were scored and compared before and 6 months and 12 months after the insertion of the LNG-IUS. The adverse reactions to LNG-IUS were observed. Results： The ache scores before and 6 months after the insertion of the LNG-IUS were 1.00 （0.00, 3.00） and 0.00 （0.00, 2.00） , respectively, the difference was not statistically significant （ P 〉 0.05 ） ; while the acne scores were 0.00 （0.00, 1.00） 12 months after the insertion of the LNG-IUS, the difference was statistically significant （P 〈 0.01 ）. The facial pigmentation scores before and 6 months and 12 months after the insertion of the LNG-IUS were 1.00 （0.00, 1.00） ; the differences were not stastically significant （all P 〉0.05）. The premenstrual mammary swelling scores before and 6 months and 12 months after the insertion of the LNG-IUS were 2. 20 （0.00, 4.00）, 1.50 （0.00, 4.00） and 1.00 （0.00, 3.00）, respectively; the differences were statistically significant （ P 〈 0. 05, P 〈0.01）. The body weight before and 6 months and 12 months after the insertion of the LNG-IUS were 59.00 （55.00, 64.00） kg, 59.50 （ 55.00, 64.00） kg, and 59.00 （54.00, 64.00 ） kg, respectively ; the differences were not statistically significant （ all P 〉0.05）. The quality of life before the insertion of the LNG-IUS was compared with the quality of life 6 months and 12 months after the insertion of the LNG-IUS; the differences were statistically significant （ all P 〈 0.01 ）. The intra-menstrual bleeding before and6 months and 12 months after the insertion of the LNG-IUS were 4 cases （6.78%）, 16 cases （27. 12%）, and 14 cases （23.73%）, respectively. Ot