| 血管内皮抑素转基因制剂的体外抗肿瘤作用及对大鼠大肠癌的影响 |
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| 引用本文： | 官成浓,罗海清,廖湘晖,陈星明.血管内皮抑素转基因制剂的体外抗肿瘤作用及对大鼠大肠癌的影响[J].医学研究杂志,2008,37(10). |
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| 作者姓名： | 官成浓 罗海清 廖湘晖 陈星明 |
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| 作者单位： | 广东医学院附属医院肿瘤诊治中心,湛江,524001 |
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| 摘 要： | 目的 研究血管内皮抑素转基因双歧杆菌口服冻干粉剂(endostatin transfected bifidobacterium oral powder prepara-tion,ETB-2)体外抗肿瘤作用及对大鼠大肠痛的影响.方法 采用MTT法检测ETB-2对人结肠癌细胞株LS-174T、人胃黏膜上皮细胞株GES-1的作用.以二甲肼(DMH)为诱发剂,观察ETB-2对大鼠大肠癌的防治作用;DMH诱癌及ETB-2灌胃时间为18周,在第33周结束实验.结果 ETB-2在体外对人结肠癌细胞株具有显著的选择性杀伤作用,体内给药可明显降低大鼠大肠癌发生率(60%:100%,P<0.01),但大肠癌平均个数及肿瘤体积指数的差异无显著性(P>0.05).结论 ETB-2对DMH诱导的大鼠大肠癌具有预防作用.
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| 关 键 词： | 血管内皮抑素转基因双歧杆菌口服冻干粉剂(ETB-2) 大肠癌 二甲基肼 |
The Antitumor Effects in vitro and Impact on Colon Cancer In Rats of Endostatin Transfected Bifidobacterium Oral Powder Preparation |
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| Guan Chengnong,Luo Haiqing,Liao Xianghui,Chen Xinming.The Antitumor Effects in vitro and Impact on Colon Cancer In Rats of Endostatin Transfected Bifidobacterium Oral Powder Preparation[J].Journal of Medical Research,2008,37(10). |
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| Authors: | Guan Chengnong Luo Haiqing Liao Xianghui Chen Xinming |
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| Institution: | Guan Chengnong,Luo Haiqing,Liao Xianghui,Chen Xinming.Affiliated Hospital of Guangdong Medical College,Zhanjiang 524001,China |
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| Abstract: | Objective To study the antitumor effects in vitro and impact on colon cancer in rats of endostatin transfected bifidobacterium oral powder preparation(ETB-2).Methods Growth inhibitory effect of the cecropins on normal human gastric epithelial cell line(GES-1) and human colon adenocarcinoma cell line(LS-174T) was observed using a microculturetetrazolium(MTT) colorimetric methods.Male Wistar rats were divided into 4 groups.All treatments were completed in a course of 18 weeks and the experiment was finished a... |
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| Keywords: | Endostatin transfected bifidobacterium oral powder preparation(ETB-2) Colon cancer 1 2-dimethylhydrazine(DMH) |
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