| 可溶性环氧化物水解酶抑制剂与心血管疾病 |
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| 引用本文： | 王振河,姜德谦,赵婷婷,沈丽. 可溶性环氧化物水解酶抑制剂与心血管疾病[J]. 心血管病学进展, 2011, 32(4): 579-582. DOI: 10.3969/j.issn.1004-3934.2011.04.036 |
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| 作者姓名： | 王振河 姜德谦 赵婷婷 沈丽 |
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| 作者单位： | 湖南长沙中南大学湘雅二医院心内科,湖南,长沙,410011 |
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| 基金项目： | 国家自然科学基金，教育部新世纪优秀人才支持计划 |
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| 摘 要： | 环氧二十碳三烯酸已被证明通过减少缺血再灌注损伤、抗炎、扩张血管等机制发挥心血管保护作用。可溶性环氧化物水解酶是使环氧二十碳三烯酸代谢和失活的主要酶类。因此可溶性环氧化物水解酶抑制剂抑制可溶性环氧化物水解酶,将提高环氧二十碳三烯酸的有益特性,成为治疗心血管疾病的有效措施。
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| 关 键 词： | 可溶性环氧化物水解酶 环氧二十碳三烯酸 心血管疾病 |
Soluble Epoxide Hydrolase Inhibitors and Cardiovascular Disease |
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| WANG Zhen-he,JIANG De-qian,ZHAO Ting-ting,SHEN Li. Soluble Epoxide Hydrolase Inhibitors and Cardiovascular Disease[J]. Advances in Cardiovascular Diseases, 2011, 32(4): 579-582. DOI: 10.3969/j.issn.1004-3934.2011.04.036 |
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| Authors: | WANG Zhen-he JIANG De-qian ZHAO Ting-ting SHEN Li |
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| Affiliation: | WANG Zhen-he,JIANG De-qian,ZHAO Ting-ting,SHEN Li,XU Dan-yan (Department of Cardiology,The Second Xiangya Hospital,Central South University,Changsha 410011,Hunan,China) |
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| Abstract: | Epoxyeicosatrienoic acids(EETs) have been shown to play a role in cardiovascular protection through reducing ischemia reperfusion injury,as an anti-inflammatory,and vessel extension,among others.Soluble epoxide hydrolase is the major enzyme to metabolize and deactivate EETs.Therefore soluble epoxide hydrolase inhibitor(sHEI) would be expected to enhance the beneficial properties of EETs through inhibiting she,which might be an effective measurement to treat cardiovascular diseases. |
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| Keywords: | soluble epoxide hydrolase epoxyeicosatrienoic acids cardiovascular diseases |
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