| 酰基辅酶A胆固醇酰基转移酶-1与动脉粥样硬化 |
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| 引用本文： | 高小花. 酰基辅酶A胆固醇酰基转移酶-1与动脉粥样硬化[J]. 心血管病学进展, 2011, 32(4): 604-606. DOI: 10.3969/j.issn.1004-3934.2011.04.043 |
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| 作者姓名： | 高小花 |
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| 作者单位： | 长治医学院心血管病研究所,山西,长治,046000;长治医学院附属和平医院心内科,山西,长治,046000 |
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| 基金项目： | 国家自然科学基金，山西省高校科技研究项目 |
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| 摘 要： | 酰基辅酶A胆固醇酰基转移酶目前认为是细胞内唯一合成胆固醇酯的酶,维持着细胞以及生物体胆固醇代谢的平衡,而酰基辅酶A胆固醇酰基转移酶-1在动脉粥样硬化的发生、发展过程中发挥着至关重要的作用。自从酰基辅酶A胆固醇酰基转移酶的cDNA在1993年首次被克隆之后,许多学者对酰基辅酶A胆固醇酰基转移酶-1进行了大量的研究,现就近年来酰基辅酶A胆固醇酰基转移酶-1与动脉粥样硬化关系的研究予以综述。
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| 关 键 词： | 酰基辅酶A胆固醇酰基转移酶-1 动脉粥样硬化 |
Acyl-coenzyme A:Cholesterol Acyltransferase-1 and Atherosclerosis |
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| GAO Xiao-hua. Acyl-coenzyme A:Cholesterol Acyltransferase-1 and Atherosclerosis[J]. Advances in Cardiovascular Diseases, 2011, 32(4): 604-606. DOI: 10.3969/j.issn.1004-3934.2011.04.043 |
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| Authors: | GAO Xiao-hua |
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| Affiliation: | GAO Xiao-hua1,2,WANG Yong-jin1,2 (1.Institute of Cardioangiology of Changzhi Medical College,Changzhi 046000,Shanxi,China,2.Department of Cardiology,Changzhi Medical College Subsidiary Heping Hospital,China) |
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| Abstract: | Acyl-coenzyme A:cholesterol acyltransferase-1(ACAT-1) is currently considered to be the only synthesizer of cholesterol esters from cholesterol.It maintains the balance between free cholesterol and cholesterol esters in cells.It has been shown that ACAT-1 plays an important role in the development of atherosclerosis.This review summarizes the research and current progress of ACAT-1 in relation to atherosclerosis. |
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| Keywords: | acyl-coenzyme A:cholesterol acyltransferase-1 atherosclerosis |
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