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Protein Expression of Epidermal Growth Factor Receptor in Laryngeal Squamous Cell Carcinoma Index Tumors Correlates with Diagnosis of Second Primary Tumors of the Upper Aero-Digestive Tract |
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| Authors: | Ross Darius Farhadieh BScHons MBBS Arash Salardini BSc MBBS Charles Geoffrey Gordon Rees BScHons MBBS Pamela J Russell BSc PhD Jia Lin Yang MB BSc Med PhD Robert Smee MBBS FRANZCR |
| Institution: | (1) Prince of Wales Hospital, Post Graduate Clinical School, UNSW, Sydney, Australia;(2) St Vincent’s Hospital, Melbourne, Australia;(3) Yale University, Connecticut, USA;(4) UNSW, Sydney, Australia;(5) Oncology Research Centre, Prince of Wales Hospital, UNSW, Randwick, Sydney, Australia;(6) Faculty of Medicine, UNSW, Sydney, Australia;(7) Department of Radiation Oncology, Prince of Wales Hospital, Sydney, Australia;(8) C/O Sister Janette Williams, Department of Radiation Oncology, Prince of Wales Hospital, Sydney, Australia |
| Abstract: | BackgroundField cancerization is a feature of HNSCCs. No biological marker in the index tumor has correlated with second primary tumor (SPTs) development. Changes in MDM-2 and epidermal growth factor receptor (EGFR) expression are known to be early neoplastic changes in HNSCC. EGFR expression is correlated with clinical outcomes. This study has assessed the predictive correlation of MDM-2 and EGFR protein expression with clinicopathological parameters and occurrence of SPTs in HNSCC. |
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