| 1,3-丁二酮类衍生物对S-180肉瘤细胞生长抑制作用体外实验研究 |
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| 引用本文： | 严轶琛,朱志博,雷林生.1,3-丁二酮类衍生物对S-180肉瘤细胞生长抑制作用体外实验研究[J].西北药学杂志,2011,26(4):276-278. |
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| 作者姓名： | 严轶琛 朱志博 雷林生 |
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| 作者单位： | 南方医科大学药学院化学系,广东,广州,510515 |
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| 摘 要： | 目的观察1,3-丁二酮类衍生物对S180肿瘤细胞生长的影响,为进一步的研究提供依据。方法细胞增殖程度采用MTT比色法。结果 1,3-丁二酮衍生物B具有较强的抑制S180细胞增殖的作用;1,3-丁二酮衍生物A对S180细胞增殖抑制作用较弱。结论 1,3-丁二酮衍生物B对小鼠S180肿瘤细胞体外增殖有明显抑制作用。
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| 关 键 词： | 1 3-丁二酮 抗肿瘤 MTT比色法 |
Effects of ramification of 1,3-dioxo-1-phenylbutan on the proliferation of murine S180 sarcoma cells |
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| YAN Yichen,ZHU Zhibo,LEI Linsheng.Effects of ramification of 1,3-dioxo-1-phenylbutan on the proliferation of murine S180 sarcoma cells[J].Northwest Pharmaceutical Journal,2011,26(4):276-278. |
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| Authors: | YAN Yichen ZHU Zhibo LEI Linsheng |
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| Institution: | YAN Yichen,ZHU Zhibo,LEI Linsheng(Department of Chemistry,School of Pharmaceutical Sciences,Southern Medical University,Guangdong Guangzhou 510515,China) |
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| Abstract: | Objective To study the effects of ramification of 1,3-dioxo-1-phenylbutan on the proliferation of murine S180 sarcoma cells,and to provide evidence for the further study.Methods Cell proliferation was detected by methyl thiazolyltetrazolium assay(MTT).Results The compound B had strong inhibitory effect on the growth of murine S180 sarcoma cells,whereas the compound A showed weaker effects.Conclusion Ramification of 1,3-dioxo-1-phenylbutan has markedly inhibitory effect on the growth of mouse S180 sarcoma ce... |
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| Keywords: | 1 3-dioxo-1-phenylbutan antitumor methyl thiazolyltetrazolium assay |
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