| 银屑病易感基因的研究进展 |
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| 引用本文： | 赵文超,孙立,韩建文,海荣,乌日娜. 银屑病易感基因的研究进展[J]. 内蒙古医学院学报, 2011, 33(3): 264-267 |
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| 作者姓名： | 赵文超 孙立 韩建文 海荣 乌日娜 |
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| 作者单位： | 1. 内蒙古医学院,内蒙古,呼和浩特,010059
2. 内蒙古医学院附属医院,皮肤科 |
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| 摘 要： | 多数研究认为银屑病是一个多基因,主要涉及MHC（人类HLA）的遗传性皮肤病,并在八个染色体上确定了九个银屑病易感基因位点（PSORS1-9）。PSORS1（银屑病易感基因位点1）是一个主要的银屑病易感位点,大多数的研究显示HLA-Cw6是PSORS1候选区域主要的危险等位基因。本文主要介绍PSORS1及HLA中重点研究的银屑病相关等位基因的研究进展,并简要概括其他银屑病易感基因位点的研究发现。
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| 关 键 词： | 银屑病 HLA PSORS |
ADVANCE IN PSORIASIS SUSCEPTIBILIY GENE |
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| Affiliation: | ZHAO Wen-chao,SUN Li,HAN Jian-wen,et al.(Inner Mongolia Medical College,Hohhot 010059 China) |
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| Abstract: | Many studies show that psoriasis is a polygenic genodermatosis mainly involving MHC（HLA in humans）,and have identified nine psoriasis susceptibility gene loci on eight chromosomes.PSORS1（psoriasis susceptibility gene 1）is a major susceptibility locus for psoriasis.The most study has indicated HLA-Cw6 as the primary PSORS1 risk allele within the candidate region.This paper describes the key progresses of the psoriasis-related alleles researches in PSORS1 and the HLA and a brief summary of psoriasis susceptibility loci in other studies. |
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| Keywords: | HLA PSORS |
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