Bcl—2,Bax在大肠癌组织的表达对术后化疗疗效的影响

为探讨凋亡抑制基因ｂｃｌ┐２和促进基因ｂａｘ在大肠癌组织中的表达及与术后化疗疗效的关系。方法采用免疫组化Ｓ┐Ｐ法，检测了４３例手术后随访５年以上的大肠癌组织中ｂｃｌ┐２、ｂａｘ基因产物的表达，统计术后化疗者与未化疗者的复发率和五年生存率。结果术后化疗者３１例，ｂｃｌ┐２阳性者复发率（３４．６％）明显高于ｂｃｌ┐２阴性者（２０．０％）（Ｐ＜０．０５）；ｂｃｌ┐２阳性者五年生存率（６９．２％）明显低于ｂｃｌ┐２阴性者（８０．０％）（Ｐ＜０．０５）。ｂａｘ阳性者复发率（７．１％）明显低于ｂａｘ阴性者（５２．９％）（Ｐ＜０．０５），而ｂａｘ阳性者五年生存率（９２．９％）明显高于ｂａｘ阴性者（５２．９％）（Ｐ＜０．０５）。未化疗组１２例，ｂｃｌ┐２、ｂａｘ阳性与阴性者的复发率，五年生存率均无显著差异。结论检测大肠癌组织中ｂｃｌ┐２、ｂａｘ表达有助于预测术后化疗疗效和预后。

EXPRESSION OF bcl 2,bax GENE PRODUCTS IN COLORECTAL CARCINOMA TISSUES AND THEIR INFLUENCE ON EFFICIENCY OF POSTOPERATIVE CHEMOTHERAPY

Objective:To explore the expression of apoptosis inhibited gene bcl 2 and promoted gene bax in colorectal carcinoma tissues and their influence on efficiency of postoperative chemotherapy. Methods:The expression of bcl 2 and bax gene products in 43 cases of colorectal carcinoma specimens, that had been operated and followed over five years was examined by S P immuno histochemical technique, and then analysed for their recurrent rate and five years survival rate. Results:Tumor recurrent rate in bcl 2 gene positive cases was 34.6%, higher than bcl 2 negative cases (20.0%)( P <0 05);five year survival rate was 69.2% in bcl 2 positive, lower than in bcl 2 negative (80.0%)( P <0 05). Recurrence rates of bax positive and negaitive cases were 7.1% and 52.9% respectively ( P <0 05);five year survival rates were respectively 92.9% and 52.9% ( P <0.05). Conclusions:Monitoring bcl 2 and bax expression is useful to viewing chemotherapy efficiency and prognosis.