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| 大气混合污染物对大鼠肺泡灌洗液及血清中CC16表达水平的影响 | |
| 引用本文： | 陈魁敏,王任群,赵肃,肖纯凌.大气混合污染物对大鼠肺泡灌洗液及血清中CC16表达水平的影响[J].沈阳医学院学报,2008,10(4):195-197. |
| 作者姓名： | 陈魁敏 王任群 赵肃 肖纯凌 |
| 作者单位： | 1. 沈阳医学院机能实验中心,辽宁,沈阳110034 2. 职业卫生与环境卫生学教研室 3. 病原生物学教研室 |
| 基金项目： | 国家自然科学基金资助项目 |
| 摘 要： | 目的：探讨大气混合污染物所致肺损伤的敏感生物指示物。方法：使Wistar大鼠染尘、染毒，制备大气混合污染物所致肺损伤的动物模型。将48只Wistar大鼠随机分为3个实验组（1d组、15d组、30d组）和3个对照组，每组8只。采用ELISA方法检测肺支气管肺灌洗液（BALF）和血清中CC16蛋白的表达。结果：BALF中，染毒1d组CC16蛋白水平降低，与对照组比较差异显著（P〈0．05）；血清中，染毒30d大鼠CC16蛋白与对照组比较显著升高（P〈0．05）结论：CC16可作为急性肺损伤的敏感生物指示物之一。 |
| 关 键 词： | 大气混合污染物 BALF 血清 CC16 |
Effects of air mixed certain pollutants on the expression of CC16 in BALF and serum of rats |
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| CHEN Kui-min,WANG Ren-qun,ZHAO Su,XIAO Chun-ling.Effects of air mixed certain pollutants on the expression of CC16 in BALF and serum of rats[J].Journal of Shenyang Medical College,2008,10(4):195-197. | |
| Authors: | CHEN Kui-min WANG Ren-qun ZHAO Su XIAO Chun-ling |
| Institution: | CHEN Kui-min1,WANG Ren-qun2,ZHAO Su3,XIAO Chun-ling3 |
| Abstract: | Objective： To determine CC16 in BALF and serum of rats exposed to air mixed pollutants on lung damage. Methods： 48 Wistar rats with 200 -240g weight were randomly divided into 3 experimental groups （1d , 15d, 30d dose group） and 3 control groups. Each group had 8 rats. ELISA was utilized to measure CC16 level in BALF and serum. Results： The level of CC16 in BALF of ld experimentalwas lower than that of control group （p 〈 0. 05 ）. CC16 level in serum was hight than that of control group （P 〈0. 05）. Conclusion： The level of CC16 may be used as a peripheral biomarker in the acute lung injury. |
| Keywords: | BALF CC16 |
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