| 初代培养的胸腺基质细胞对小鼠胸腺细胞的粘附和吞噬作用 |
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| 引用本文： | 蒋定文,郭明秋,陈立茵,沈先荣. 初代培养的胸腺基质细胞对小鼠胸腺细胞的粘附和吞噬作用[J]. 细胞与分子免疫学杂志, 2002, 18(1): 20-22 |
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| 作者姓名： | 蒋定文 郭明秋 陈立茵 沈先荣 |
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| 作者单位： | 1. 海军医学研究所海洋生物研究中心,上海,200433
2. 第一军医大学基础部抗衰老研究室,广东,广州,510515 |
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| 摘 要： | 目的 探讨胸腺基质细胞（TSC）对胸腺细胞的调节作用。方法 应用光镜、电镜和流式细胞术等，观察初代培养的TSC对胸腺细胞发育的调节作用。结果 光镜和电镜均可见，TSC可大量粘附和吞噬胸腺细胞，其中部分胸腺细胞发生凋亡。尽管与TSC共培养的胸腺细胞存活率高，凋亡率低，但其总数却显著减少。结论 TSC可通过粘附和吞噬作用，清除部分胸腺细胞。
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| 关 键 词： | 胸腺基质细胞 胸腺细胞 凋亡 调节 |
| 文章编号： | 1007-8738(2002)01-020-03 |
| 修稿时间： | 2001-06-05 |
Adhesion and phagocytosis of primarily cultured thymic stromal cells to thymocytes murine |
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| JIANG Ding-wen GUO Ming-qiu,CHEN Li- yin,SHEN Xian - Tong Marine Biology Research Center,Naval Medical Research Institu- te,Shanghai,,China. Adhesion and phagocytosis of primarily cultured thymic stromal cells to thymocytes murine[J]. Chinese journal of cellular and molecular immunology, 2002, 18(1): 20-22 |
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| Authors: | JIANG Ding-wen GUO Ming-qiu CHEN Li- yin SHEN Xian - Tong Marine Biology Research Center Naval Medical Research Institu- te Shanghai China |
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| Affiliation: | JIANG Ding-wen GUO Ming-qiu,CHEN Li- yin,SHEN Xian - Tong Marine Biology Research Center,Naval Medical Research Institu- te,Shanghai,200433,China. Institute of Antisenility,First Mili- tary Medical Univers |
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| Abstract: | Aim To explore the regulatory effect of thymic stronial cells ( TSC) on thymocytes. Methods Light microscopy, electron microscopy and flow cytometry ( FCM) were used to observe the reg- ulatory effect of cultured primary TSCs on thymocytic development. Results A large number of thymocytes adhered to and were en- gulfed by TSCs. Some engulfed thymocytes showed apoptosis. Al- though thymocytes cocultured with TSCs had high survival rate and low apoptotic rate, their total number decreased significantly. Con- clusion ThCs can delete some thymocytes via their adhesion and phagocytosis. |
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| Keywords: | thymic stromal cells thymocytes apoptosis regula-tion |
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