在线血液透析滤过在慢性肾衰竭综合救治中的临床实用研究

【摘要】目的探讨在线血液透析滤过（online-HDF）在慢性肾衰竭综合救治中的临床效果及安全性。方法随机选取在我院进行血液透析的82例慢性肾衰竭患者，分为血液透析（HD）组（38例）和HDF／HD组（44例），HD组进行常规血液透析，HDF／HD组两次血液透析后进行一次血液滤过，对比两组治疗后血肌酐（Scr）、血尿素氮（BUN）、血清磷的变化及并发症情况。结果HDF／HD组治疗后Scr,BUN与对照组相比差异无统计学意义，血清磷与对照组相比差异有统计学意义（P〈0．05），HDF／HD组发生低血压反应等并发症明显少于HD组。结论在线血液透析滤过在慢性肾衰竭综合救治中安全方便，效果显著。

Clinical application of on-line hemodiafiltration in the treatment of chronic renal failure

Objective To explore the clinical efficacy and safety of on-line hemodiafihration （on- line-HDF） in treatment of chronic renal failure. Methods 82 patients with chronic renal failure who had beentreated in our hospital were randomly assigned to HD group （38 patients） and HDF/HD group （44 patients）. HD group underwent conventional hemodialysis, while HDF/HD group received hcmodialysis twice and then hemodiafihration. The changes in blood levels of Cr, BUN, and phosphorus and the complications were compared between the two groups after treatment. Results There were no statistical differences in levels of Cr and BUN in HDF/HD group after treatment; whereas serum phosphorus level differed significantly between HDF/HD group and HD group （P〈O.05）. The incidence rate of complications was lower in HDF/HD group than in HD group. Gonclusions On-line hemodiafiltration is safe and convenient and has remarkable efficacy in the treatment of chronic renal failure.