川芎嗪与尼群地平配伍对慢性阻塞性肺病患者血流动力学的影响

目的：寻找降低慢性阻塞性肺病（简称慢阻肺）患者肺血管阻力而不增加药物副作用的药物。方法：通过右心漂浮导管检测部分临床缓解期的慢阻肺患者（15例）在应用川芎嗪与尼群地平配伍的血流动力学参数变化。结果：慢阻肺患者用药即刻、15、30、60min时，肺动脉平均压下降了1．4％、17．0％、20．0％、18．0％；肺循环阻力下降了15．2％、36．2％、43．0％、34．6％；体循环阻力下降了7．9％、19＝2％、17．8％、20．8％；心输出量上升了15．8％、22．6％、33．8％。体循环动脉压及心率差异无显著性。结论：川芎嗪与尼群地平配伍能够有效地低慢阻肺患者的肺血管阻力及肺动脉压，对肺循环有一定的选择性。

Effect of Combination of Ligustrazine and Nitrendipine on Hemodynamics in Patients with Chronic Obstructive Pulmonary Disease

Objective: To find the drugs for lowering the pulmonary vascular resistance in patients of chronic obstructive pulmonary disease (COPD) but would not increase its side effect. Methods: Changes of some hemodynamic parameters in 15 patients of COPD in stable stage treated by nitrendipine and ligustrazine were observed by right heart floating catheterization. Results: The mean pulmonary arterial pressure reduced by 1.4% immediately after the combined treatment, and reduced by 17 0%, 20 0% and 18 0% in 15 mins, 30 mins and 60 mins after treatment. In the responding time, the pulmonary vascular resistance reduced by 15.2%, 36.2%, 43 0% and 34.6%, the systemic vascular resistance reduced by 7 9%, 19 2%, 17 9% and 20 8%, and the cardiac output increased by 15 8%, 22 6%, 22 2%, and 33.8% respectively. The changes of systemic arterial pressure and heart rate were of no statistical significance. Conclusion: Combination therapy of nitrendipine and ligustrazine could lower the pulmonary arterial pressure and pulmonary vascular resistance effectively and has a selective effect on pulmonary circulation in patients with COPD.