The normal breast microenvironment of premenopausal women differentially influences the behavior of breast cancer cells in vitro and in vivo |
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| Authors: | Jodie M Fleming Tyler C Miller Mariam Quinones Zhen Xiao Xia Xu Matthew J Meyer Erika Ginsburg Timothy D Veenstra Barbara K Vonderhaar |
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| Affiliation: | (1) Mammary Biology and Tumorigenesis Laboratory, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA;(2) Bioinformatics and Computational Biosciences Branch, The Office of Science Management and Operations, National Institute of Allergy and Infectious Disease, Bethesda, MD, USA;(3) Laboratory of Proteomics and Analytical Technologies, Advanced Technology Program, SAIC-Frederick, NCI-Frederick, Frederick, MD, USA |
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| Abstract: | Background Breast cancer studies frequently focus on the role of the tumor microenvironment in the promotion of cancer; however, the influence of the normal breast microenvironment on cancer cells remains relatively unknown. To investigate the role of the normal breast microenvironment on breast cancer cell tumorigenicity, we examined whether extracellular matrix molecules (ECM) derived from premenopausal African-American (AA) or Caucasian-American (CAU) breast tissue would affect the tumorigenicity of cancer cells in vitro and in vivo. We chose these two populations because of the well documented predisposition of AA women to develop aggressive, highly metastatic breast cancer compared to CAU women. |
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