比较甲钴胺不同给药途径治疗后天性眼肌麻痹的疗效

目的:探讨甲钴胺不同给药途径治疗后天性眼肌麻痹的效果。方法:眼肌麻痹患者24例24眼,年龄52±10岁,女13例,男11例。患者分为4组,每组6眼。离子导入组(A组)、球周注射组(B组)、甲钴胺0.5mg肌内注射组(C组)、维生素B110mg和B12500μg肌内注射组(D组)。每日监测眼肌功能、复视、角膜映光法斜视度数。结果:比较眼肌功能、复视、角膜映光法斜视度数,A,B组分别与C,D组两组之间差异有统计学意义(P<0.01),A,B组之间比较,差异无显著性(P>0.05)。C,D组之间比较,差异无显著性(P>0.05)。结论:离子导入甲钴胺是一种有效、安全、简便的眼外肌麻痹的治疗方案。非外伤性眼外肌麻痹,球周注射是一种可供选择的治疗途径。甲钴胺局部用药效果好于全身给药。

Efficacy comparison of mecobalamin on acquired ophthalmoplegia via varied administration routes

AIM:To investigate the effect of mecobalamin via different medication method on acquired ophthalmoplegia.METHODS:Twenty-four cases(24 eyes),clinically diagnosed as ophthalmoplegia,aged from 42 to 70 years,average 58,with 13 female and 8 male were analyzed.Patients were randomly divided into group A(ion transmission),B(peribulbar injection),C(muscular injection of 0.5mg mecobalamin),D(muscular injection of 10mg vitamin B1 and 500μg vitamin B12),with 6 eyes in each group.Extravenous ocular muscle function,diplopia and oblique angles were daily monitored.RESULTS:In terms of extravenous ocular muscle function,diplopia and oblique angles,significant differences existed as comparing group A or B with group C or D respectively.Neither significant differences showed between group A and B nor between group C and D.CONCLUSION:Ion transmission of mecobalamin was confirmed as an effective,safe and convenient medication scheme.As for non-traumatic paralysis of extravenous ocular muscle,peribulbar injection can also be an option.The mecobalamin effect by local medication was found better than that by systemic one.