Current status of radio-frequency ablation for hepatocellular carcinoma |
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Authors: | K K Ng S T Fan |
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Institution: | (1) Centre for the Study of Liver Disease, Department of Surgery, University of Hong Kong, Hong Kong, People's Republic of China |
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Abstract: | Summary BACKGROUND: Radio-frequency ablation (RFA) is the latest developed and widely practised local ablation therapy for liver tumours.
It has the merit of effective tumour ablation and preservation of the maximal normal liver parenchyma. In the past few years,
there has been tremendous expansion in the application of RFA for hepatocellular carcinoma (HCC) patients. However, the therapeutic
effect of this local-ablation treatment needs to be balanced against its risks and possible local failure. METHODS: This review
focuses on the current status of RFA for HCC, with attention to its indications, approaches, risks, local failure, and survival
benefit. RESULTS: Although the results of most clinical studies of RFA seem optimistic, the associated complication and tumour
recurrence should not be overlooked. Careful patient selection, meticulous RFA techniques, and prompt treatment of residual
and recurrent tumours are necessary to ensure a better outcome after RFA. CONCLUSIONS: Until recently, there has been no strong
evidence showing that RFA can replace any treatment modalities in the management of HCC. Nonetheless, more convincing evidence
by randomised trials is required for the establishment of a treatment protocol of RFA for HCC patients.
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Keywords: | Radio-frequency ablation Hepatocellular carcinoma |
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