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Identification of iGb3 and iGb4 in melanoma B16F10-Nex2 cells and the iNKT cell-mediated antitumor effect of dendritic cells primed with iGb3 |
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| Authors: | Bianca R Dias Elaine G Rodrigues Leonardo Nimrichter Ernesto S Nakayasu Igor C Almeida Luiz R Travassos |
| Affiliation: | 1. Experimental Oncology Unit (UNONEX), Department of Microbiology, Immunology and Parasitology, Universidade Federal de S?o Paulo, S?o Paulo, Brazil 2. Instituto de Microbiologia Prof Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil 3. The Border Biomedical Research Center, Department of Biological Sciences, University of Texas at El Paso, Texas, USA |
| Abstract: | BackgroundCD1d-restricted iNKT cells are protective against murine melanoma B16F10-Nex2 growing subcutaneously in syngeneic C57Bl/6 mice as inferred from the fast tumor development in CD1d-KO in comparison with wild type animals. CD1d glycoproteins are related to the class I MHC molecules, and are involved in the presentation, particularly by dentritic cells (DC), of lipid antigens to iNKT cells. In the present work we attempted to identify the endogenous lipid mediator expressed in melanoma cells inducing such immunesurveillance response and study the possibility of protecting animals challenged with tumor cells with lipid-primed DC. |
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