光动力疗法治疗豚鼠寻常型银屑病

摘要：目的观察5-氨基酮戊酸光动力疗法（ALA-PDT）治疗寻常型银屑病模型的疗效，探讨ALA-PDT治疗寻常型银屑病
的可行性。方法5%心得安搽剂外涂豚鼠耳背部皮肤建立寻常型银屑病模型。20%ALA溶液局部封包模型皮损4 h后，
635 nm半导体激光照射患处，能量密度12 J/cm2。分设模型对照组、单纯ALA组、单纯照光组、一次ALA-PDT治疗组和
二次ALA-PDT治疗组5个组别，于治疗后第7、14、21及28天进行外观与组织活检观察。结果在肉眼观察、表皮厚度和
增殖细胞核抗原（PCNA）表达三项指标观察中，ALA-PDT 均能明显改善寻常型银屑病模型的病变，二次治疗组疗效优于
一次治疗组。结论ALA-PDT 疗法能治愈以表皮过度增殖为特征的豚鼠耳背部寻常型银屑病模型皮损，增加治疗次数疗
效更佳。

Therapeutic effect of photodynamic treatment for psoriasis vulgaris in guinea pigs

Objective To observe the efficacy of 5-aminolevulinic acid photodynamic therapy(ALA-PDT) for treating psoriasis vulgaris in guinea pigs. Methods Experimental psoriasis vulgaris was induced in guinea pigs by application of 5% propranolol on the ear skin. After dressing of the skin lesion with 20% ALA solution for 4 h,the lesions were irradiated with a semiconductor laser at the wavelength of 635 nm and energy density of 12 J/cm2. The guinea pigs were divided into control group,ALA only group,light only group...