Cardiovascular effects of leukotrienes |
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Authors: | J. Fauler J. C. Frölich MD |
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Affiliation: | (1) Department of Clinical Pharmacology, Hannover Medical School, D-3000 Hannover 61, West Germany |
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Abstract: | Summary Leukotrienes have been shown to signif. icantly influence coronary vascular resistance, infarct size, pulmonary vascular resistance, bronchial tone, and renal vascular resistance either directly or indirectly. There is a notable dirth of data on human pathophysiologic conditions. With the advent of specific inhibitors of the synthesis and action of leukotrienes and, more importantly, of methods on the in-vivo synthesis of these potentially important mediators, these gaps in our understanding will be closed. |
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Keywords: | cardiovascular leukotrienes pharmacology coronary vasoconstriction peptidoleukotrienes |
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