平阳霉素磁性微球治疗海绵状血管瘤的实验研究

目的 :探讨自制的平阳霉素磁性微球 (MPMs)治疗海绵状血管瘤的可行性及机制。方法 :将 2 0只新西兰白兔分为 4组 ,分别将MPMs、平阳霉素及空白微球注入兔耳缘静脉 ,2 1d后处死动物 ,在光镜、透射电镜下观察兔耳静脉的组织学变化。结果 :MPMs、平阳霉素及空白微球对血管壁均有损伤作用 ,以MPMs组引起血管闭锁最为明显。结论 :MPMs可通过平阳霉素的药物作用以及本身的栓塞作用使血管闭锁 ,可作为海绵状血管瘤硬化治疗的一种较理想药物

Experimental study of magnetic pingyangmycine-bearing microspheres in the treatment of cavernous hemangioma

Objective To investigate the probability and machanism magnetic pingyangmycine bearing microspheres(MPMs) in the treatment of cavernous hemangioma. Methods Twenty rabbits were divided into four groups.MPMs,pingyangmycine and magnetic nonpingyangmycine bearing microspheres were injected into marginal ear veins respectively.All animals were killed after 21 days and histological varations of the veins were observed under the light microscope and transmission electron microscope. Results The occlusion of the veins in the group of MPMs with the external magnetic field was more prominent than that in the other groups. Conclusion MPMs can occlude veins by means of its embolized effect and PYM drug effect.MPMs may be better used in the therapy of cavernous hemangioma.