可吸入大气颗粒物污染与居民每日死亡关系的Meta分析

目的综合分析国内外可吸入大气颗粒物（PM10）短期暴露与人群死亡关系的流行病学资料，以获取大气PM10污染与居民死亡的暴露-反应关系。方法在计算机联机检索文献和手工检索的基础上，对近十年来发表的相关研究文献采用meta分析的方法进行综合评价，并检验、校正可能存在的发表偏倚，从而准确、定量地确定PM10污染与居民死亡的暴露-反应关系。结果建立了居民短期接触大气PM10污染的暴露一反应关系，即在未考虑发表偏倚的情况下，大气中PM10每增加1130μg／m3，居民死亡的相对危险度增加3．87％（95％CI：2．84％～5．02％），在校正了发表偏倚后大气中PM10每增加100μg／m3，死亡的相对危险度增加下降为1．41％（95％CI：0．30％-2．43％），与考虑偏倚前相比下降了63．6％。结论本研究建立的暴露-反应关系较早注意到发表偏倚的影响，具有一定的代表性与科学性，可用于大气颗粒物暴露健康危险度评价工作参考，为制定相关环境决策提供科学依据。

Meta analysis of the relationship between airborne inhalable particulate pollution and daily mortality

Objective： To do the epidemiological analysis based on the data of air inhalable particulate matter （PM10） and daily mortality, and to estimate the exposure -response relationship. Method：Based on the online search and manpower search in a library of relevant studies with the same endpoint, meta-analysis was used to do the com- prehensive assessment to determine the exposure-response relationship. Result：The exposure-response relationship between short-term exposure to ambient PM10 and the increased percentage of daily mortality was found, as the concentration of air PM10 increased by 100μg/m3, the dally mortality of residents increased by 3.87% （95% CI：2. 84% - 5. 02% ）when publication bias was not considered. But when we corrected the publication bias by filling the funnel plot, as the concentration of air PMI0 increased by 100μg/m3, the daily mortality of residents increased by 1.41% （95 % C1：0.30% -2.43% ）. Conclusion：The exposure-response relationship recommended in the present paper can be applied to the health risk assessment of air PM10 in various cities of China.