| 一氧化氮对骨肉瘤细胞表面CD44表达的影响 |
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| 引用本文： | 张新宇,匡正达,杨传铎. 一氧化氮对骨肉瘤细胞表面CD44表达的影响[J]. 中国康复理论与实践, 2005, 11(7): 552-552,F0003 |
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| 作者姓名： | 张新宇 匡正达 杨传铎 |
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| 作者单位： | 100039,北京市,武警总医院骨科 |
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| 摘 要： | 目的研究一氧化氮（NO）对体外培养的骨肉瘤细胞株表面CD44表达的影响及意义。方法在体外培养骨肉瘤细胞株培养液中加入不同浓度的硝普钠（SNP）以产生外源性NO，用免疫组织化学的方法研究细胞表面CD44抗原成分的变化。结果肿瘤细胞表面CD44抗原在SNP存在的情况下表达明显下降。结论NO可以一定程度上抑制骨肉瘤细胞株CD44的表达，可能引起肿瘤细胞转移能力的改变。
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| 关 键 词： | 一氧化氮 骨肉瘤 硝普钠 CD44 |
| 文章编号： | 1006-9771（2005）07-0552-01 |
| 收稿时间： | 2005-01-13 |
| 修稿时间： | 2005-01-13 |
Effect of nitric oxide on expression of CD44 of osteosarcoma cell line |
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| ZHANG Xin-yu,Kuang Zheng-da,Yang Chuan-duo. Effect of nitric oxide on expression of CD44 of osteosarcoma cell line[J]. Chinese Journal of Rehabilitation Theory and Practice, 2005, 11(7): 552-552,F0003 |
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| Authors: | ZHANG Xin-yu Kuang Zheng-da Yang Chuan-duo |
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| Abstract: | ObjectiveTo study the influence of nitric oxide on the expression of CD44 of human osteosarcoma cell line (HOS).MethodsDifferent concentrations of sodium nitroprusside (SNP) were added into the culture solution of HOS in vitro. Through immunohistochemistry method (SP), the expression of CD44 were observed.ResultsThe expression of CD44 was depressed when the concentration of SNP was increased. ConclusionNitric oxide can depress the expression of CD44 of HOS and maybe change the invasive or metastatic abilities of HOS. |
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| Keywords: | nitric oxide Osteosarcoma sodium nitroprusside CD44 |
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