Trapidil,a platelet-derived growth factor antagonist,inhibits osteoclastogenesis by down-regulating NFATc1 and suppresses bone loss in mice |
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| Authors: | Sun-Don Kim Ha-Neui Kim Jong-Ho Lee Won Jong Jin Soon Jung Hwang Hong-Hee Kim Hyunil Ha Zang Hee Lee |
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| Affiliation: | 1. Department of Cell and Developmental Biology, Dental Research Institute, School of Dentistry, Seoul National University, Seoul 110-749, Republic of Korea;2. Korean Medicine-Based Herbal Drug Development Group, Korea Institute of Oriental Medicine, Daejeon 305-811, Republic of Korea |
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| Abstract: | |
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| Keywords: | M-CSF, macrophage colony stimulation factor RANKL, receptor activator of NF-κB ligand MAPK, mitogen-activated protein kinase NFATc1, nuclear factor of activated T cells, cytoplasmic 1 Ca2+, calcium PLCγ, phospholipase Cγ CaMK, Ca2+/calmodulin-dependent kinase PDGF, platelet-derived growth factor PGE2, prostaglandin E2 CREB, cAMP response element-binding protein OPG, osteoprotegerin BMMs, bone marrow-derived macrophages TRAP, tartrate-resistant acid phosphatase PTH, parathyroid hormone |
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