| rhIL-6对血小板低下豚鼠的治疗作用 |
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| 引用本文： | 张建华 崔淑莲. rhIL-6对血小板低下豚鼠的治疗作用[J]. 中国生化药物杂志, 1998, 19(1): 12-14 |
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| 作者姓名： | 张建华 崔淑莲 |
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| 作者单位： | 山东省医学科学院山东肿瘤生物治疗中心!济南，250062(张建华，王郡甫，冯进波，田志刚)，广东燕塘生物化学制药厂(崔淑莲，黄漫祥) |
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| 摘 要： | 采用抗血小板血清和致死照射两方法建立了两种豚鼠血小板低下模型，进而观察了rhIL－6治疗时豚鼠生存率及生存期的影响，以及与血小板数量的关系。结果表明，rhIL－6可明显提高豚鼠的生存率并延长生存期，rhIL－6的这种生物学效应主要与其提高豚鼠血小板数量有关，与其它血常规指标无关。
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| 关 键 词： | rhIL－6 血小板 造血损伤 |
The Effects of rhIL-6 in the Treatment of Low-platelet Models of Guineapigs |
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| Zhang Jianhua, Cui Shulian, Wang Junfu, Feng Jinbo, Huang Manxiang, Tian Zhigang. The Effects of rhIL-6 in the Treatment of Low-platelet Models of Guineapigs[J]. Chinese Journal of Biochemical Pharmaceutics, 1998, 19(1): 12-14 |
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| Authors: | Zhang Jianhua Cui Shulian Wang Junfu Feng Jinbo Huang Manxiang Tian Zhigang |
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| Affiliation: | Shandong Cancer Biotherapy Center of Shandong Academic Medical Sciences Jinan 250062 |
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| Abstract: | Two low-platelet models of guinea-pigs were made by means of anti-platelet serum and lethal irradiation respectively. The effects of rhIL-6 on the survial rates and periods and platelet counts were observed. The results showed that rhIL- 6 could prolong the survial periods and increase the survial rates of low- platelet guinea- pigs. These effects were related to the increase of peripheral platelets, not other peripheral cells. |
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| Keywords: | rhIL- 6 Platelet Hemopoietic failure |
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