| 载脂蛋白E基因多态性与脑白质疏松症的关系 |
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| 引用本文： | 陈志斌,涂蓉,钱士匀,蔡美华,姚红霞,苏庆杰,王琰,欧小凡. 载脂蛋白E基因多态性与脑白质疏松症的关系[J]. 中国现代医学杂志, 2004, 14(3): 66-68 |
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| 作者姓名： | 陈志斌 涂蓉 钱士匀 蔡美华 姚红霞 苏庆杰 王琰 欧小凡 |
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| 作者单位： | 海南医学院附属医院,海南,海口,570102 |
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| 基金项目： | ThispaperwassupportedbyHainanProvinceHealthDepartmentofFinancialAid (No :qw19980 9) |
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| 摘 要： | 目的探讨载脂蛋白E基因多态性与脑白质疏松症的关系.方法采用聚合酶链反应-限制片段长度多态性对50例脑白质疏松症患者和108例正常对照者载脂蛋白E基因型进行分析.结果脑白质疏松症患者ApoE2等位基因频率为0.15,明显高于对照组的0.074(P＜0.05);在脑白质疏松症患者中检测出携带有Apoε2/2纯合子基因者4例,携带有Apoε4/4纯合子基因者2例,高于对照组.结论载脂蛋白E2等位基因,尤其是ε2/2纯合子基因可能是脑白质疏松症的一种遗传易感因子.
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| 关 键 词： | 脑白质疏松症 载脂蛋白E 基因多态性 |
Relationship between polymorphisms of apolipoprotein E gene and leuKoaralosis |
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| Abstract. Relationship between polymorphisms of apolipoprotein E gene and leuKoaralosis[J]. China Journal of Modern Medicine, 2004, 14(3): 66-68 |
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| Authors: | Abstract |
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| Abstract: | Objective:To study the relationship between polymorphisms of apolipoprotein E gene and leukoaraiosis.Methods :The polymerase chain reaction(PCR)and restriction fragment length polymorphism(RFLP)technique were used Objective:To detect apo-E in 50 leukoaraiosis patients and 108 normal people in control group.Results:The frequency of Apo E 2 allele in the leukoaraiosis group was significantly higher than that in the control group(P ＜0.05).4 case with genotype Apoε2/2 and 2 case with Apoε4/4 in leukoaraiosis group were found.The frequency of Apoε2/2 and Apoε4/4 in the leukoaraiosis group were higher than that in the control group.Conclusions: Allele Apo E 2,especially genotype Apoε2/2,seemed Objective:To be a genetic susceptible facObjective:Tor for leukoaraiosis. |
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| Keywords: | apolipoprotein E leukoaraiosis gene polymorphism |
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