| 左旋甲状腺素替代治疗对亚临床甲减患者颈动脉内中膜厚度的影响 |
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| 引用本文： | 徐爱霞,唐莉,王晓华,李方雄,. 左旋甲状腺素替代治疗对亚临床甲减患者颈动脉内中膜厚度的影响[J]. 中国医学工程, 2008, 0(3) |
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| 作者姓名： | 徐爱霞 唐莉 王晓华 李方雄 |
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| 作者单位： | 湖南省长沙市中心医院内分泌科;中南大学湘雅医院心内科; |
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| 摘 要： | 目的评价左旋甲状腺素(L-T4)替代治疗对亚临床甲减患者颈动脉内中膜厚度(IMT)的影响。方法对45例亚临床甲减患者进行血脂及颈动脉IMT的检测,观察其基线及L-T4治疗后的变化,并与甲状腺功能正常对照组比较。结果亚临床甲减患者血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDLc)、载脂蛋白β和C反应蛋白(CRP)的浓度升高,颈动脉IMT增加;逐步回归分析显示IMT平均值与LDLc、促甲状腺激素释放激素(TSH)水平呈正相关。L-T4治疗能显著降低TC、LDLc及颈动脉IMT,IMT的下降与血清TSH及TC值的下降直接相关。结论L-T4替代疗法能改善亚临床甲减患者动脉粥样硬化脂质谱和内中膜增厚,其颈动脉壁的脂质渗透仍可能是IMT增加的一个重要机制。
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| 关 键 词： | 亚临床甲减 颈动脉内中膜厚度 血脂 替代治疗 |
Effect of levothyroxine replacement on intima-media thickness in subclinical hypothyroidism |
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| XU Ai-Xia,TANG Li,WANG Xiao-hua,LI Fang-xiong. Effect of levothyroxine replacement on intima-media thickness in subclinical hypothyroidism[J]. China Medical Engineering, 2008, 0(3) |
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| Authors: | XU Ai-Xia TANG Li WANG Xiao-hua LI Fang-xiong |
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| Affiliation: | XU Ai-Xia1,TANG Li1,WANG Xiao-hua1,LI Fang-xiong2(1.Department of Endocrinology,the Central Hospital of Changsha City,Changsha,Hunan 410005,P.R.China,2.Department of Internal Cardiology,Xiangya Hospital of Central South university,Hunan 410008,P.R.China) |
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| Abstract: | 【Objective】 To study the effect L-T4 replacement therapy to carotid artery intima-media thickness(IMT).【Methods】Carotid artery IMT and lipoprotein profile were assessed in 45 Subclinical hypothyroidism(sHT) patients at baseline and after 6 months L-T4 replacement with comparison to 45 age-and sex-matched controls.【Results】sHT patients had elevated total and low-density lipoprotein(LDL) cholesterol and ApoB levels and higher mean-IMT values.In stepwise regression analysis,mean-IMT was positively related to L... |
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| Keywords: | subclinical hypothyroidism intima-media thickness lipid replacement therapy |
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