孕妇血脂多糖结合蛋白水平与胎膜早破的关系

目的:探讨血清脂多糖结合蛋白（LBP）与胎膜早破（PROM）的关系，为早期诊断PROM、亚临床型绒毛膜炎提供新的思路。方法:选取60例PROM患者为研究对象，其中早产PROM（pPROM）组30例，足月PROM（tPROM）组30例；另取同期住院的正常足月妊娠孕妇（正常组）30例作为对照。ELISA法检测3组孕妇分娩前血清LBP水平；分娩后，留取胎膜组织做病理检查。结果:pPROM组、tPROM组和正常组血清LBP水平分别为（125.22±37.51）、（102.87±20.90）、（66.09±31.17）μg/mL，差异有统计学意义（P<0.01）；组间比较发现，pPROM组和tPROM组孕妇血清LBP水平均明显高于正常组（P<0.01）。PROM组孕妇绒毛膜炎程度与血清LBP水平呈正相关关系（P<0.01）；随着破膜时间的越长，血清LBP水平呈增高趋势（P<0.01）。结论:血清LBP水平对PROM的诊断及其是否合并亚临床型绒毛膜羊膜炎有一定的提示价值。

The relationship between the concentration of lipopolysaccharide binding protein and premature rupture of membrane in pregnant women

Objective:To explore the relationship between the concentration of lipopolysaccharide binding protein ( LBP ) and premature rupture of membrane( PROM) ,and provide a reference in diagnosing PROM and subclinical intra-amniotic infection( IAI) . Methods:Sixty PROM patients were divided into the premature PROM ( pPROM ) group and term PROM ( tPROM ) group ( 30 cases each group) ,and 30 normal full-term pregnancy women were set as the control group. The serum LBP levels before delivery in three groups were detected using ELISA. Fetal membrane samples after delivery were examined using pathology technique. Results:The concentrations of LBP in pPROM group,tPROM group and control group were(125. 22 ± 37. 51)μg/mL,(102. 87 ± 20. 90)μg/mL and (66.09±31.17)μg/mL,respectively,the differences of which were statistically significant(P<0.01).The LBP concentrations in pPROM group and tPROM group were significantly higher than that in control group(P <0. 01). There was a positive correlation between the serum LBP concentration and inflammation degree of the chorionic membrane in pPROM group(P < 0. 01). The concentration of serum LBP increased gradually(P<0. 01). Conclusions:The serum level of LBP has a certain value in diagnosing PROM and PROM complicated with subclinical intra-amniotic infection.