强直性脊柱炎患者骨密度的影响因素分析

目的:分析强直性脊柱炎（AS）患者腰椎和股骨颈骨密度（BMD）改变与年龄、性别、病程、髋关节病变及急性时相反应物之间的关联。方法:选取91例确诊AS患者，采用双能X线吸收法测定腰椎（L₂~L₄）、股骨颈BMD值，骨质疏松诊断标准用T值表示。结果:男性AS患者腰椎、股骨颈BMD均低于女性AS患者（P<0.05）。AS合并髋关节病变患者与无髋关节病变患者股骨颈BMD差异无统计学意义（P>0.05）。患者年龄与腰椎BMD T值呈负相关关系（P<0.05），而患者病程、急性时相反应物与AS患者BMD均无相关关系（P>0.05）。结论:AS患者男性比女性更易发生骨量减少和骨质疏松，随着年龄的增加，腰椎骨质疏松发生增多。病程、髋关节病变以及急性时相反应物对AS患者BMD改变无显著影响。

Analysis of the relevant factor affecting bone mineral density in patients with ankylosing spondylitis

Objective:To analyze the correlation of the bone mineral density(BMD) changes of lumbar and femoral neck with age, gender,disease duration, hip lesion and acute phase reactant in patients with ankylosing spondylitis ( AS ) . Methods:The BMD of lumbar( L2 - L4 ) and femoral neck were detected using Dual-energy X-ray absorptiometry method, and T value was used as the diagnosis criteria of osteoporosis. Results:The BMD of lumbar and femoral neck in male AS patient was significantly lower than that in female AS patient(P<0. 05). The difference of the BMD of femoral neck between the patients with AS complicated with and without hip lesion was not statistically significant(P>0. 05). The T value of BMD of lumbar was negatively correlated with the age of patient (P<0.05),but the disease duration and acute phase reactant were not correlated with the BMD of AS patient(P > 0. 05). Conclusions:Compared with female AS patient, the osteopenia and osteoporosis in male AS patient are ease to happen, and the occurrence rate of osteoporosis of lumbar increases with the age of patient increasing. Disease duration, hip lesion and acute phase reactant have no significant influence on the BMD change in AS patient.