血清同型半胱氨酸水平与急性脑梗死相关性分析

目的:探讨血清同型半胱氨酸（Hcy）水平与急性脑梗死的关系及其与血清叶酸、维生素B₁₂的相关性。方法:选择120例经头颅CT或MRI证实为急性脑梗死的患者（急性脑梗死组）和98名同期门诊健康体检者（对照组），2组均采用荧光偏振免疫法测定血清Hcy水平，采用电化学发光免疫法测定血清叶酸及维生素B₁₂水平。结果:急性脑梗死组血清Hcy水平明显高于对照组（P<0.01），其血清维生素B₁₂及叶酸水平均明显低于对照组（P<0.01）。急性脑梗死组血清Hcy与叶酸、维生素B₁₂水平均呈负相关关系（P<0.05）。结论:高Hcy血症是急性脑梗死的独立危险因素，给予补充叶酸和维生素B₁₂可降低血清Hcy，从而降低脑梗死的发生率。

Correlation analysis of plasma homocysteine level with acute cerebral infarction

Objective: To explore the relationship between the plasma homocysteine(Hcy) level and acute cerebral infarction,and its correlation with plasma folic acid and vitamin B₁₂.Methods: One hundred and twenty patients with acute cerebral infarction diagnosed by head CT or MRI and 98 healthy people were divided into the acute cerebral infarction group and control group,respectively.The levels of plasma homocysteine,and plasma folic acid and vitamin B₁₂ in two groups were measured by fluorescence polarization immunoassay(FPLA) and electrochemical luminescence immunoassay(ECLI),respectively.Results: The levels of plasma homocysteine,plasma folic acid and vitamin B₁₂ in acute cerebral infarction group were significantly higher than those in control group(P<0.01).The folic acid and vitamin B₁₂ levels of acute cerebral infarction group were significantly lower than those in confrol group(P<0.01).The level of plasma homocysteine was negative correlation with the levels of plasma folic acid and vitamin B₁₂ in acute cerebral infarction group(P<0.05).Conclusions: The hyperhomocysteinemia is an independent risk factor of acute cerebral infarction.Supplementing the folic acid and vitamin B₁₂ can reduce the serum homocysteine,which can reduce the incidence of cerebral infarction.