甲状腺乳头状癌中Survivin、VEGF、EGFR的表达及临床意义分析

目的：分析甲状腺乳头状癌（PTC）中存活素（Survivin）、血管内皮生长因子（VEGF）、表皮生长因子受体（EGFR）的表达及临床意义。方法选取70例PTC患者标本组织及70例癌旁正常甲状腺组织作为研究样本，使用免疫组化Envision两步法检测Survivin、VEGF、EGFR的表达。结果在70例PTC患者中Survivin、VEGF、EGFR的阳性表达率分别为58.57%、75.71%、84.29%，明显高于癌旁正常甲状腺组织的0.00%、0.00%、0.00%，差异有统计学意义（P﹤0.05）。伴有淋巴结转移的PTC患者Survivin、VEGF阳性表达率分别为85.71%、95.24%，高于无淋巴结转移的46.94%、67.35%（P﹤0.05），而不同年龄、性别及肿瘤直径患者Survivin、VEGF阳性表达率比较，差异无统计学意义（P﹥0.05）。女性患者的EGFR阳性表达率为92.86%（52/56），显著高于男性患者的50.00%（7/14），差异有统计学意义（P﹤0.01），而不同年龄、肿瘤直径及有无淋巴结转移患者的EGFR阳性表达率比较，差异无统计学意义（P﹥0.05）。VEGF与Survivin、EGFR的表达无相关性（P﹥0.05），Survivin与EGFR表达呈正相关（r=0.734，P﹤0.05）。结论 PTC的发生发展过程均与Survivin、VEGF、EGFR的表达存在密切关联性，肿瘤淋巴结转移可能与Survivin、VEGF的表达有关。

The expression and clinical significance of Survivin,VEGF, and EGFR in thyroid papillary carcinoma

Objective To analyze the expression and clinical significance of Survivin, vascular endothelial growth factor (VEGF), and epidermal growth factor receptor (EGFR) in papillary thyroid carcinoma (PTC). Method The tissues of 70 cases of PTC and 70 cases of normal thyroid tissues adjacent to cancer were included in the analysis, the expression of survivin, VEGF and EGFR were detected by immunohistochemistry, the Envision two-step method. Result In 70 cas-es of PTC, the positive expression rates of Survivin, VEGF, and EGFR were 58.57%, 75.71%, and 84.29%, significantly higher than those in normal thyroid tissues at 0.00%, 0.00%, 0.00%, respectively (P<0.05). In patients with lymph node metastasis, the positive expression rates of Survivin and VEGF were 85.71%and 95.24%, significantly higher than those without lymph node metastasis at 46.94% and 67.35% (P<0.05), while the positive expression of Survivin and VEGF were similar in patients with different age, gender or varied tumor diameter (P>0.05). The positive expression rate of EG-FR in female patients was 92.86%(52/56), significantly higher than that in male patients at 50.00%(7/14), with statistical-ly significant difference observed (P<0.01), and the positive expression of EGFR was similar in patients with different age, tumor diameter and lymph node metastasis, while the difference was not statistically significant (P>0.05). There was no correlation observed between the expression of VEGF and Survivin or EGFR (P>0.05), and Survivin expression was positively correlated with that of EGFR (r=0.734, P<0.05). Conclusion The occurrence and development of PTC are closely related to the expression of Survivin, VEGF and EGFR, and lymph node metastasis may be associated with the ex-pression of VEGF and survivin.