精神分裂症患者血清超敏C反应蛋白水平研究

目的:研究精神分裂症患者血清超敏C反应蛋白（hs-CRP）水平以及抗精神病药物对hs-CRP水平的影响。方法:采用颗粒增强免疫透射比浊法检测106例首次发病精神分裂症患者（首次发病组）、138例长期服用抗精神病药物治疗患者（长期服药组）和137名体检正常健康成人（对照组）血清hs-CRP水平，比较3组差异，并对单独服用氯氮平和利培酮治疗的患者血清hs-CRP水平进行分析。同时采集标本当天对精神分裂症患者进行阳性和阴性症状量表（PANSS）评分。结果:长期服药组血清hs-CRP水平明显高于对照组（P<0.01），同时长期服药组血清hs-CRP水平高于首次发病组（P<0.05）；氯氮平治疗组血清hs-CRP水平均明显高于利培酮治疗组和首次发病组（P<0.01），利培酮治疗组和首次发病组血清hs-CRP水平差异无统计学意义（P>0.05）；hs-CRP>2.066 4 mg/L精神分裂症患者PANSS阳性量表分、阴性量表分、一般病理量表分和总分均高于hs-CRP<2.066 4 mg/L组（P<0.05～P<0.01），相关性分析表明血清hs-CRP的表达与精神分裂症的病情均呈正相关关系（P<0.05）。结论:精神分裂症患者血清hs-CRP水平明显升高，氯氮平治疗能上调hs-CRP的水平，hs-CRP水平与精神分裂症的病情具有相关性。

Study of the serum level of high sensitivity C-reactive protein in schizophrenic

Objective:To investigate the level of serum high sensitivity C reactive protein(hs-CRP) in schizophrenic,and effect of antipsychotic drugs on the level of hs-CRP. Methods:The serum levels of hs-CRP in the first onset 106 schizophrenia patients( the first onset group) ,108 patients treated with antipsychotic drugs( long-term medication group) and 137 healthy people( control group) were detected,the difference of which was compared. The serum levels of hs-CRP in patients treated with individual clozapine and risperidone were analyzed. The scores of the positive and negative syndrome scale( PANSS) in schizophrenia patients was investigated. Results:The serum level of hs-CRP in long-term medication group was significantly higher than that in control group(P<0. 01),and the serum level of hs-CRP in long-term medication group was higher than that in the first onset group(P <0. 05). The serum level of hs-CRP in clozapine group was significantly higher than that in risperidone group and the first onset group(P<0. 01). The difference of the hs-CRP level between the risperidone group and first onset group was not statistically significant(P>0. 05). The scores of the positive scale and negative scale of PANSS,general pathology scale and total score in schizophrenia patients with hs-CRP>2. 066 4 mg/L were significantly higher than those in patients with hs-CRP < 2. 066 4 mg/L group(P<0. 05 to P<0. 01). Correlation analysis showed the expression of serum hs-CRP was positively correlated with schizophrenia severity(P<0. 05). Conclusions:The serum levels of hs-CRP in schizophrenia patients significantly increased,and the clozapine treatment can upregulate the serum level of hs-CRP. The level of hs-CRP is correlated with psychotic state.