通便化痔颗粒对痔疮模型大鼠的疗效

目的 对酸灼伤大鼠皮肤能否行成痔疮模型进行方法学研究及通便化痔颗粒对此模型的药理作用.方法 采用10 mol/L盐酸灼伤人工划伤的大鼠肛门周围皮肤及肛门内侧的黏膜,连续灌胃给予通便化痔颗粒10 d后,进行肉眼观察及光镜观察评分.通便化痔颗粒能使被盐酸灼伤并发生病理性改变的皮肤得到有效地恢复.结果 病理结果显示痔疮模型成功；通便化痔颗粒在大、中剂量下能使大鼠被盐酸灼伤发生病理性改变的皮肤得到有效地恢复.结论 酸灼伤大鼠皮肤模拟痔疮模型成立；通便化痔颗粒能够有效恢复大鼠痔疮模型皮肤组织.

Tongbianhuazhi Keli on the Hemorrhoids Rat Animal Model Efficacy Studies

Objective To establish a haemorrhoids model with the method of acid burns on rats’skin,and to study the pharmacological effects of Tongbianhuazhi Keli on this model.Method 10mol /L hydrochloric acid burned the scratched skin around rats anus and the anal medial mucosa.Tongbianhuazhi Keli was orally administered to the rats for 10d.Then score the skin with macroscopic observation and light microscope.Result Pathological results showed that the haemorrhoids model was established successfully.And the pathologic changes on hydrochloric acid burned rats skin can be effectively restored by oral application of large and middle dose of Tongbianhuazhi Keli.Conclusion The haemo haemorrhoids model with the method of acid burns on rats skin was successful;Tongbianhuazhi Keli was effective to restore the rats skin of haemorrhoids model.