碱性磷酸酶测定对良恶性胸水鉴别诊断的价值

本文测定了59例良恶性胸水中碱性磷酸酶(ALP)活性,并与癌胚抗原(CEA)进行同步对照,结果显示:恶性胸水中ALP活性高于良性胸水,两者差异有极显著意义(P<0.01),胸水ALP活性明显升高可强烈提示恶性胸水的诊断,具有较高特异性。胸水中ALP和CEA的升高呈非同步性,提示同时检测ALP和CEA具有互补诊断价值。

The value of alkaline phosphatase in discrimination between benign and malignant pleural effusion

Alkaline phosphatase(ALP)activities in pleural effusion were measured in 59 cases with benign and malignant diseases. As a control,carcinoembryo antigen(CEA)concentrations in pleural effusion were also determined. The result showed that pleural ALP activities were higher in malignant cases than in benign ones(P<0. 01),Marked elevation of ALP strongly suggests malignant effusion. The levels of ALP and CEA are not consistent in pleural effusion, thus simultaneous determination of ALP and CEA has a complementary value for the diagnosis of pleural effusion.