| 制霉菌素口腔双层贴膜的制备与质量控制 |
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| 引用本文： | 叶继锋,侯齐书,戴伟伟,林奕沨. 制霉菌素口腔双层贴膜的制备与质量控制[J]. 海峡药学, 2012, 24(3): 18-20 |
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| 作者姓名： | 叶继锋 侯齐书 戴伟伟 林奕沨 |
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| 作者单位： | 温州医学院附属第二医院 温州325035 |
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| 摘 要： | 目的制备制霉菌素口腔双层贴膜并建立其质量考察方法。方法采用乙基纤维素作为空白隔离层成膜材料,采用聚乙烯醇和羧甲基纤维素钠作为成膜材料制备含药膜,采用紫外分光光度法测定其中制霉菌素的含量。结果制霉菌素在1.02～20.40μg.mL-1内呈良好的线性关系（r=0.9999）,平均回收率为100.12%,（RSD=0.32%,n=6）。结论该膜剂制备方法简单可行,质量可控。
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| 关 键 词： | 制霉菌素 双层膜 制备工艺 质量 |
Preparation and quality control of double-layer film of Oral Nystatin |
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| YE Ji-feng , HOU Qi-shu , DAI Wei-wei , LIN Yi-feng. Preparation and quality control of double-layer film of Oral Nystatin[J]. Strait Pharmaceutical Journal, 2012, 24(3): 18-20 |
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| Authors: | YE Ji-feng HOU Qi-shu DAI Wei-wei LIN Yi-feng |
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| Affiliation: | feng(The Second Affiliated Hospital of Wenzhou Medical College,Wenzhou 325035,China) |
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| Abstract: | OBJECTIVE To prepare double-layer film of oral nystatin and to establish its quality control method.METHODS With Ethyl cellulose ethoce as a blank spacer film-forming material,Use of polyvinyl alcohol and sodium carboxymethyl cellulose as a film forming material preparation.Main drug nystatin content was determined by ultraviolet spectrophotometry.RESULTS The linear range of nystatin was 1.02~20.40μg·mL-1（r=0.9999）,the average recoveries of nystatin was 100.12%,（RSD=0.32%,n=6）.CONCLUSION The preparing method is simple,and quality control is reasonable. |
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| Keywords: | Nystatin Double-layer film Preparation technology Quality control |
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