| 复方感冒灵胶囊质量标准研究 |
| |
| 引用本文： | 高咏莉,王淑红. 复方感冒灵胶囊质量标准研究[J]. 中国药师, 2012, 15(4): 474-477 |
| |
| 作者姓名： | 高咏莉 王淑红 |
| |
| 作者单位： | 深圳市药品检验所,广东深圳,518057 |
| |
| 基金项目： | 国家药典委员会2010~2011年标准提高行动计划研究课题 |
| |
| 摘 要： | 目的:建立复方感冒灵胶囊的质量标准.方法:采用薄层色谱法,对三叉苦进行定性鉴别;采用HPLC法对马来酸氯苯那敏进行含量测定及含量均匀度检查.结果:该薄层色谱法专属性强、阴性无干扰,可对三叉苦进行定性鉴别;液相色谱条件有效改善了色谱峰拖尾现象,马来酸氯苯那敏在0.103 0～2.574 μg范围内线性关系良好(r=0.999 9),平均回收率为102.0%(RSD=2.08%).结论:该方法简便、准确、稳定且无干扰,可作为该制剂的质量控制方法.
|
| 关 键 词： | 复方感冒灵胶囊 质量标准 薄层色谱 高效液相色谱 |
| 收稿时间： | 2011-12-26 |
| 修稿时间： | 2012-01-29 |
Study on Quality Standard of Compound Ganmaoling Capsules |
| |
| Gao Yongli and Wang Shuhong. Study on Quality Standard of Compound Ganmaoling Capsules[J]. China Pharmacist, 2012, 15(4): 474-477 |
| |
| Authors: | Gao Yongli and Wang Shuhong |
| |
| Affiliation: | (Shenzhen Institute for Drug Control,Guangdong Shenzhen 518057,China) |
| |
| Abstract: | Objective： To establish the quality standard for compound Ganmaoling capsules.Method： Evodia lepta was identified by TLC.The content and content uniformity of chlorphenamine maleate was determined by HPLC.Result： The method of TLC was distinct and highly specific.The chromatographic conditions could effectively improve the streaking.A linearity was obtained within the range of 0.103 0~2.574 μg for chlorphenamine maleate（r=0.999 9）.The average recovery was 102.0%（RSD=2.08%）.Conclusion： The method is simple,sensitivity and stable,and can be used in the quality control of compound Ganmaoling capsules. |
| |
| Keywords: | Compound Ganmaoling capsules Quality standard TLC HPLC |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《中国药师》浏览原始摘要信息 |
|
点击此处可从《中国药师》下载全文 |
