| UGT1A1 G71R 基因多态性对母乳性黄疸程度的影响 |
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| 引用本文： | 傅雯萍,吴彬彬,王恒. UGT1A1 G71R 基因多态性对母乳性黄疸程度的影响[J]. 临床儿科杂志, 2010, 28(3) |
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| 作者姓名： | 傅雯萍 吴彬彬 王恒 |
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| 作者单位： | 天津武警医学院附属医院儿科,天津,300162 |
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| 摘 要： | 目的探讨葡萄糖醛酸转移酶UGT1A1 G71R基因突变对晚发型母乳性黄疸患儿黄疸程度的影响。方法收集晚发型母乳性黄疸患儿56例,用套式PCR后限制性片段长度多态性分析(RFLP)确定UGT1A1 G71R基因型,通过全自动生化分析仪测定胆红素水平。结果UGT1A1 G71R突变纯合子5例,杂合子24例,野生型27例。UGT1A1 G71R等位基因频率为30.36%。UGT1A1 G71R纯合子或杂合子组(n=29)与UGT1A1G71R野生组(n=27)的胆红素水平分别为(237.85±31.92)μmol/L、(214.49±32.48)μmol/L,前者明显高于后者(t=2.7141,P=0.0089)。结论晚发型母乳性黄疸患儿如存在UGT1A1 G71R基因突变,临床上黄疸程度较重。
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| 关 键 词： | 晚发型母乳性黄疸 UGT1A1基因 胆红素 |
The effect of UDP-glucoronosyl transferase 1A1 G71R mutation on bilirubin level in infants with breast-milk jaundice |
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| FU Wen-ping,WU Bing-bing,WANG Heng. The effect of UDP-glucoronosyl transferase 1A1 G71R mutation on bilirubin level in infants with breast-milk jaundice[J]. The Journal of Clinical Pediatrics, 2010, 28(3) |
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| Authors: | FU Wen-ping WU Bing-bing WANG Heng |
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| Affiliation: | Department of Pediatrics/a>;The Affiliated Hospital of Medical College of Chinese People's Armed Police Force/a>;Tianjin 300162/a>;China |
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| Abstract: | |
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| Keywords: | late-onset breast-milk jaundice UGT1A1 gene bilirubin |
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