The crosstalk of gut microbiota and chronic kidney disease: role of inflammation,proteinuria, hypertension,and diabetes mellitus |
| |
Authors: | Mehmet Kanbay Emine M Onal Baris Afsar Tuncay Dagel Aslihan Yerlikaya Adrian Covic Nosratola D Vaziri |
| |
Institution: | 1.Division of Nephrology, Department of Medicine,Koc University School of Medicine,Istanbul,Turkey;2.Koc University School of Medicine,Istanbul,Turkey;3.Division of Nephrology, Department of Medicine,Suleymen Demirel University School of Medicine,Isparta,Turkey;4.Nephrology Department, Dialysis and Renal Transplant Center, “Dr. C.I. Parhon” University Hospital,“Grigore T. Popa” University of Medicine and Pharmacy,Iasi,Romania;5.Division of Nephrology and Hypertension,University of California,Irvine,USA |
| |
Abstract: | Chronic kidney disease (CKD) has been shown to result in profound changes in the composition and functions of the gut microbial flora which by disrupting intestinal epithelial barrier and generating toxic by-products contributes to systemic inflammation and the associated complications. On the other hand, emerging evidence points to the role of the gut microbiota in the development and progression of CKD by provoking inflammation, proteinuria, hypertension, and diabetes. These observations demonstrate the causal interconnection between the gut microbial dysbiosis and CKD. The gut microbiota closely interacts with the inflammatory, renal, cardiovascular, and endocrine systems via metabolic, humoral, and neural signaling pathways, events which can lead to chronic systemic inflammation, proteinuria, hypertension, diabetes, and kidney disease. Given the established role of the gut microbiota in the development and progression of CKD and its complications, favorable modification of the composition and function of the gut microbiome represents an appealing therapeutic target for prevention and treatment of CKD. This review provides an overview of the role of the gut microbial dysbiosis in the pathogenesis of the common causes of CKD including hypertension, diabetes, and proteinuria as well as progression of CKD. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|