Total and specific IgE (house dust mite and intestinal helminths) in asthmatics and controls from Gondar, Ethiopia |
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Authors: | Selassie Stevens Cullinan Pritchard Jones Harris Ayres & Newman Taylor |
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Institution: | Gondar College of Medical Sciences, Gondar, Ethiopia. |
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Abstract: | BACKGROUND: The role, if any, of parasitosis in the development of asthma remains incompletely understood; both 'protective' and 'predictive' associations have been reported. We report a study which examined immunoglobulin (Ig) E responses to two common helminths in asthmatics living in Ethiopia. OBJECTIVE: To compare the frequencies of specific IgE antibodies to Ascaris and Necator species and to Der p 1 among 84 adult asthmatics and a referent group of nonasthmatics. METHODS: A case-control analysis. RESULTS: Total IgE levels were not different between the two groups. The presence of specific IgE to Der p 1 was strongly associated with asthma (P = 0.001). Raised levels of Ascaris-(P = 0.010) and Necator- (P = 0.001) specific IgE antibodies were more common among referents; there were no associations between specific IgE production to Der p 1 and either of the two parasites. CONCLUSION: These findings confirm the association between Der p 1 sensitization and asthma among urban, adult Ethiopians. While they also indicate a negative relationship with two indicators of helminth infestation it appears that this is not mediated through the immunological response to common aeroallergens. |
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Keywords: | Africa Ascaris asthma Der p 1 Ethiopia helminth Necator specific immunoglobulin E |
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