Tisagenlecleucel-T for the treatment of acute lymphocytic leukemia |
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Authors: | Xavier Thomas Etienne Paubelle |
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Affiliation: | 1. Hospices Civils de Lyon, Hematology Department, Lyon-Sud Hospital, Pierre Bénite, Francexavier.thomas@chu-lyon.fr;3. Hospices Civils de Lyon, Hematology Department, Lyon-Sud Hospital, Pierre Bénite, France |
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Abstract: | ABSTRACTIntroduction: Cellular immunotherapy with autologous or allogeneic T cells, genetically engineered to express chimeric antigen receptors (CARs) or T-cell receptors, in order to redirect their cytotoxic specificity toward malignant cells, is emerging as a promising new treatment modality. The most advanced approach in clinical development is the use of anti-CD19 CAR T-cells for the treatment of CD19+ B-cell malignancies, including acute lymphocytic leukemia (ALL).Areas covered: Recently, the Food and Drug Administration (FDA) approved the first anti-CD19 CAR T-cell product, tisagenlecleucel, for the treatment of pediatric and young adult patients with relapsed/refractory ALL. In this overview, we described the advances in the field, including a summary of clinical trials with tisagenlecleucel in ALL published to date.Expert opinion: CAR T-cell therapy has been developed in the context of small clinical studies and very few centers have had to deal with the challenges of managing CAR T-cells administration. However, this approach is likely to become a standard option for patients with relapsed/refractory B-cell lineage ALL. |
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Keywords: | Acute lymphoblastic leukemia CAR T-cells CD19-directed CARs cytokine release syndrome prognosis relapse |
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