甲状腺微小乳头状癌雌激素受体的表达及临床意义

目的研究雌激素受体(ER)在甲状腺微小乳头状癌(PTMC)组织中的表达,探讨其在甲状腺肿瘤发生发展中的作用。方法采用免疫组织化学SP法检测24例正常甲状腺组织、60例PTMC(其中PTMCⅠ组27例,PTMCⅡ组33例)和76例甲状腺乳头状癌(PTC)组织中ER的表达,并结合临床病理特征进行分析。结果 PTMCⅡ及PTC组织中ER阳性率显著高于正常组织(P<0.05),PTMCⅠ组织中ER阳性率显著低于PTC组(P<0.05)。PT-MC患者中,年龄≥45岁者与<45岁者比较,原发灶直径>0.5 cm者与≤0.5 cm者比较,有包膜者与无包膜者比较,淋巴结转移者与无淋巴结转移者比较,ER阳性率间差异均有统计学意义(P<0.05)。结论 ER与甲状腺癌的发生发展密切相关,其表达与PTMC患者的年龄、肿瘤直径、有无包膜及淋巴结转移相关。

Expression and Significance of Estrogen Receptor in Papillary Thyroid Microcarcinoma

Objective To investigate the expression of estrogen receptor(ER) in papillary thyroid microcarcinoma(PTMC) and to discuss its clinical value in the occurrence and development of PTMC.Methods Immunohistochemistry was used to detect the expression of ER in 24 cases of normal tissue,60 cases of PTMC(27 cases in PTMCⅠgroup and 33 cases in PTMCⅡ group) and 76 cases of PTC.The expressions were analyzed after combining with clinicopathologic features.Results The positive expressions of ER in PTMCⅡ group and PTC group were significantly higher compared with that of the normal tissues(P<0.05).The positive expression of ER in PTMCⅠ group was significantly lower compared with that of PTC group(P<0.05).Among the patients with PTMC,the positive expression of ER all showed statistically significant differences between those who≥45 years old and those who<45 years old,those who had primary lesion>0.5 cm and those who had primary lesion≤0.5 cm,those who had diolame and those who had no diolame,those who had lymph node metastasis and those had no lymph node metastasis(P<0.05).Conclusion ER is closely related to the occurrence and development of PTC.The expression of ER is correlated with the age,carcinoma diameter,diolame and lymph node metastasis of the PTMC patients.