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Reconstruction of the adenosine system by bone marrow-derived mesenchymal stem cell transplantation
Authors:Huicong Kang  Qi Hu  Xiaoyan Liu  Yinhe Liu  Feng Xu  Xiang Li  Suiqiang Zhu
Institution:(Department of Neurology, Tongji Hospital of Tongji Medical University, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China) ;
Abstract:In the present study, we transplanted bone marrow-derived mesenchymal stem cells into the CA3 area of the hippocampus of chronic epilepsy rats kindled by lithium chloride-pilocarpine. Immunofluorescence and western blotting revealed an increase in adenosine A1 receptor expression and a decrease in adenosine A2a receptor expression in the brain tissues of epileptic rats 3 months after transplantation. Moreover, the imbalance in the A1 adenosine receptor/A2a adenosine receptor ratio was improved. Electroencephalograms showed that frequency and amplitude of spikes in the hippocampus and frontal lobe were reduced. These results suggested that mesenchymal stem cell transplantation can reconstruct the normal function of the adenosine system in the brain and greatly improve epileptiform discharges.
Keywords:bone marrow-derived mesenchymal stem cells  chronic epilepsy  cell transplantation  reconstruction  adenosine system  electroencephalogram  immunohistochemistry
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