阿立哌唑与氟哌啶醇治疗儿童抽动障碍的对照研究

目的比较阿立哌唑与氟哌啶醇治疗儿童抽动障碍的疗效和安全性。方法将68例5～16岁抽动障碍患儿随机分为两组,每组34例,分别给予阿立哌唑(5～20 mg/d)与氟哌啶醇(2～8 mg/d)治疗,采用耶鲁综合抽动严重程度量表(Yale Global Tic Severity Scale,YGTSS)、副反应量表(treatment emergent symptomscale,TESS)于治疗前、治疗第2、4、8周末评估疗效和安全性。结果从治疗第2周末起阿立哌唑组和氟哌啶醇组YGTSS总分均下降,减分率无明显差异,治疗8周后,阿立哌唑组和氟哌啶醇组治疗总体有效率分别为79%和73%,差异无统计学意义。而在2,4,8周阿立哌唑组TESS分(2.53±2.95)vs.(12.26±10.58),(1.95±2.06)vs.(7.58±5.26),(1.36±1.85)vs.(4.68±2.06)]明显低于氟哌啶醇组,均P﹤0.05。结论阿立哌唑能有效改善儿童抽动障碍,疗效与氟哌啶醇相当,而且副反应小,适合儿童治疗。

A comparative study of aripiprazole and Haloperidol treatment for tic disorders in children.

Objective To evaluate the efficacy and tolerability of Aripiprazole and Haloperidol treatment in children with tic disorders.Methods Sixty-eight children of 5-16 years old with tic disorder were randomly assigned to Aripiprazole group(5 ～ 20 mg/d) and Haloperidol group(2-8 mg/d).Treatment efficacy and tolerability was measured using the Yale Global Tic Severity Scale(YGTSS) and the Treatment Emergent Symptom Scale(TESS) at the baseline,week 2 and 4,and 8,respectively.Results Total tic scores as measured by the YGTSS decreased over time in the both groups.The overall rates of effectiveness after 8 weeks treatment were 79% and 73% at week 8 in Aripiprazole group(5 ～ 20 mg/d) and Haloperidol group(2-8 mg/d),respectively(x2=0.354,P﹥0.05).TESS scores (2.53 ± 2.95) vs.(12.26 ± 10.58),(1.95 ± 2.06) vs.(7.58 ± 5.26),(1.36 ± 1.85) vs.(4.68 ± 2.06)] were significantly lower in in the Aripiprazole group than in the haloperidol group at week 2 4 and 8 after treatment.Conclusions Aripiprazole may be a promising drug in the treatment among children with tic disorders because of its high efficacy and less tolerability.