| LKB1蛋白表达在非小细胞肺癌中的预后意义研究 |
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| 引用本文： | 李作生,张卫红,陈志全,郑贸根,侯静朴,王国臣. LKB1蛋白表达在非小细胞肺癌中的预后意义研究[J]. 中国全科医学, 2012, 15(7): 761-763 |
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| 作者姓名： | 李作生 张卫红 陈志全 郑贸根 侯静朴 王国臣 |
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| 作者单位： | 河北联合大学附属医院胸心外科,河北省唐山市,063000 |
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| 基金项目： | 河北省自然科学基金资助项目 |
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| 摘 要： | 目的探讨LKB1蛋白表达情况对非小细胞肺癌(NSCLC)患者的预后意义。方法应用免疫组化方法检测70例非小细胞肺癌患者中LKB1蛋白的表达情况。结果 LKB1蛋白在肺鳞癌和腺癌组织中的表达差异无统计学意义(P>0.05)。LKB1蛋白表达的阳性率在高分化肺癌(83.87%)、无淋巴结转移的肺癌(88.46%)和Ⅰ～Ⅱ期肺癌(75.00%)中的表达阳性率高于中-低分化肺癌(51.28%)、有淋巴结转移的肺癌(50.00%)和Ⅲ期肺癌(47.06%),差异均有统计学意义(P<0.05)。结论 LKB1蛋白在非小细胞肺癌中的低表达可能提示肺癌的预后不良。
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| 关 键 词： | LKB1蛋白 癌,非小细胞肺 基因 预后 |
Prognostic Significance of LKB1 Protein Expression in Non-Small Cell Lung Cancer |
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| Affiliation: | LI Zuo-sheng,ZHANG Wei-hong,CHEN Zhi-quan,et al.Department of Cardiothoracic Surgery,The Affiliated Hospital of Hebei United University,Tangshan 063000,China |
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| Abstract: | Objective To investigate the LKB1 protein expression and its prognostic significance in Non-small Cell Lung Cancer(NSCLC). Methods Immunohistochemical staining was used to detect the expression of LKB1 protein of the surgically resected tissue samples from 70 patients with NSCLC. Results The positivity rates of the LKB1 protein expression in squamous cell carcinoma and adenocarcinoma showed no statistical difference(P>0.05).The positivity rates of the LKB1 protein expression in lung cancers well-differentiated(83.87%),without lymph node metastasis(88.46%),and at stage Ⅰ～Ⅱ(75.00%) were higher than those in lung cancers poorly differentiated(51.28%),with lymph node metastasis(50.00%),and at stage Ⅲ(47.06%)(P<0.05). Conclusion A low expression of LKB1 protein may prompt the bad prognosis of lung cancer in NSCLC. |
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| Keywords: | LKB1 Carcinoma,non-small-cell lung Gene Prognosis |
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