Clinical features of acute human immunodeficiency virus infection in Taiwan: A multicenter study |
| |
| Affiliation: | 1. Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC;2. Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan, ROC;3. School of Medicine, National Yang-Ming University, Taipei, Taiwan, ROC;4. Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan, ROC;5. Department of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan, ROC;6. Department of Internal Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC;7. Department of Internal Medicine, Kaohsiung Medical University Hospital, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC;8. Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan, ROC;9. Department of Internal Medicine, Taoyuan General Hospital, Ministry of Health Welfare, Taoyuan, Taiwan, ROC;10. Department of Medicine, National Taiwan University Hospital Jin-Shan Branch, New Taipei City, Taiwan, ROC;11. School of Public Health, National Yang-Ming University, Taipei, Taiwan, ROC;12. Department of Internal Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chia-Yi, Taiwan, ROC;13. Department of Internal Medicine, Catholic Fu-Jen Medical College, New Taipei City, Taiwan, ROC;14. Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan, ROC;15. School of Public Health, College of Public Health and Nutrition, Taipei Medical University, Taipei, Taiwan, ROC;p. Department of Parasitology, National Taiwan University College of Medicine, Taipei, Taiwan, ROC |
| |
| Abstract: | Background/purposeAcute HIV infection is characterized by a high concentration of HIV RNA in the plasma and rapid depletion of the CD4 cell count. This multicenter, retrospective observational study aimed to characterize the manifestations of acuteHIV infection in Taiwan.MethodsBetween 1 January 2012 and 31 December 2016, all patients aged 20 years or greater who presented with acute HIV infection were included. Demographic and clinical characteristics of the patients at diagnosis were collected. Baseline laboratory assessment included hemogram, CD4 count, plasma HIV RNA load (PVL), serologic markers of syphilis and hepatitis A, B, and C viruses, and serum biochemistry.ResultsThe proportion of acute HIV infection was 6.9% among the patients with newly diagnosed HIV infection during the study period. The most common presenting symptoms of acute HIV infection were fever, fatigue, and myalgia. The median PVL at diagnosis was 5.9 log10 copies/ml, and median CD4 count was 307 cells/mm3. A total of 68 patients (27%) had baseline CD4 count less than 200 cells/mm3. Multiple logistic regression analysis, showed that the baseline CD4 count (OR, 4.02; p = 0.013) and aspartate aminotransaminase levels (OR, 3.49; p = 0.002) were associated with high PVL (>5 log10 copies/ml); and high baseline PVL (OR, 2.64; p = 0.002) was associated with symptomatic acute HIV infection.ConclusionsManifestations of acute HIV infection are nonspecific and of wide spectrum ranging from fever to severe illness. A higher proportion of patients with initial CD4 counts of 200 cells/mm3 or less during acute HIV infection warrants early, timely diagnosis and treatment to prevent rapid disease progression. |
| |
| Keywords: | Acute HIV infection Aseptic meningitis Combination antiretroviral therapy Fiebig stage Infectious mononucleosis |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
