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Force decline after low and high intensity contractions in persons with multiple sclerosis |
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| Institution: | 1. REVAL, Rehabilitation Research Center, BIOMED, Faculty of Rehabilitation Sciences, Hasselt University, Hasselt, Belgium;2. Department of Neuroscience, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands;3. Department of Kinesiology, Movement Control and Neuroplasticity Research Group, KU Leuven, Leuven, Belgium;1. Department of Clinical Neurophysiology, Aarhus University Hospital, Aarhus, Denmark;2. Danish Pain Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark;1. Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA;2. Tufts University School of Medicine, Boston, MA, USA;3. Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA, USA;1. Brain and Mind Centre, Sydney Medical School, The University of Sydney, 94 Mallett St, Camperdown, NSW 2050, Australia;2. Department of Neurology, Concord and Royal North Shore Hospitals, The University of Sydney, NSW, Australia;3. Departments of Neurology and Neurophysiology, Westmead Hospital, The University of Sydney, NSW, Australia;4. Prince of Wales Clinical School, University of New South Wales, NSW, Australia;5. MRC Centre for Neuromuscular Diseases, National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom;6. Institute of Neurology, University College London, United Kingdom;7. Department of Neurology, Royal Prince Alfred Hospital, The University of Sydney, NSW, Australia |
| Abstract: | ObjectiveForce decline during strong contractions is dominated by changes in the periphery whereas during weaker contraction changes in voluntary activation become more important. We compared force decline and contributing factors in persons with multiple sclerosis (PwMS) during low and high intensity contractions.MethodsIndex finger abduction force, force evoked by electrical stimulation of the ulnar nerve at rest (RTw), and during MVCs were investigated in 19 PwMS and 19 controls. Participants performed contractions in sets of six contractions (7 s-on, 3 s-off) at 25% or 80% MVC. After each set, a 5 s-MVC was performed with superimposed nerve stimulation followed by RTw. Contractions were repeated until MVC dropped below 80% of initial MVC.ResultsLow compared to high intensity contractions caused a greater decline in voluntary activation and a smaller decline in RTw. Compared to controls, PwMS accomplished equal sets of contractions but showed a smaller decline in RTw. Female PwMS showed poorer voluntary activation. The number of low intensity contractions was associated with sense of fatigue in PwMS.ConclusionAlthough, no difference in fatigability was observed, the mechanism contributing to force decline differed between PwMS and controls during submaximal contractions.SignificanceDuring weak contractions, fatigue and fatigability are associated in PwMS. |
| Keywords: | Fatigue Fatigability Voluntary activation Maximal strength Multiple sclerosis Superimposed twitch Sex-related differences EMG"} {"#name":"keyword" "$":{"id":"k0045"} "$$":[{"#name":"text" "_":"electromyography EDSS"} {"#name":"keyword" "$":{"id":"k1045"} "$$":[{"#name":"text" "_":"expanded disability status scale FDI"} {"#name":"keyword" "$":{"id":"k0055"} "$$":[{"#name":"text" "_":"first dorsal interosseous FSS"} {"#name":"keyword" "$":{"id":"k1055"} "$$":[{"#name":"text" "_":"Fatigue severity scale HADS"} {"#name":"keyword" "$":{"id":"k1455"} "$$":[{"#name":"text" "_":"Hospital anxiety and depression scale MFIS"} {"#name":"keyword" "$":{"id":"k6065"} "$$":[{"#name":"text" "_":"Modified fatigue impact scale MS"} {"#name":"keyword" "$":{"id":"k0065"} "$$":[{"#name":"text" "_":"multiple sclerosis PwMS"} {"#name":"keyword" "$":{"id":"k0075"} "$$":[{"#name":"text" "_":"persons with MS MVC"} {"#name":"keyword" "$":{"id":"k0085"} "$$":[{"#name":"text" "_":"maximal voluntary contraction RTw"} {"#name":"keyword" "$":{"id":"k0095"} "$$":[{"#name":"text" "_":"twitch at rest |
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