Second-generation preimplantation genetic testing for aneuploidy in assisted reproduction: a SWOT analysis |
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| Affiliation: | 1. Instituto Valenciano de Infertilidad and Departamento de Pediatría, Obstetricia y Ginecología, Facultad de Medicina, Universidad de Valencia, Valencia, Spain;2. Fertty, and Hospital de la la Santa Creu i Sant Pau, Barcelona, Spain;3. Institut Clinic Gynecology, Obstetrics and Neonatology (ICGON), Hospital Clinic, Barcelona, Spain;4. Hospital Universitario Virgen de las Nieves, Granada, Spain;5. IVI RMA Madrid, Madrid, Spain;6. Instituto Bernabeu Alicante, Alicante, Spain;7. Hospital del Mar-Parc de Salut Mar, Barcelona, Spain |
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| Abstract: | Second-generation preimplantation genetic testing for aneuploidy (PGT-A 2.0) in patients with an unfavourable reproductive and IVF prognosis is becoming common practice, with the aim of improving reproductive outcomes. However, there is still no clear evidence on the possible advantages and drawbacks with regard to this procedure. In this discussion paper, based on a SWOT (strengths, weaknesses, opportunities, threats) analysis, the different aspects of this strategy are evaluated. Current evidence suggests that PGT-A 2.0 should not at present have an indiscriminate application, but it might be indicated in cases in which the risk of aneuploidy is increased. |
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