Activity of Eravacycline against Enterobacteriaceae and Acinetobacter baumannii,Including Multidrug-Resistant Isolates,from New York City |
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| Authors: | Marie Abdallah Olawole Olafisoye Christopher Cortes Carl Urban David Landman John Quale |
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| Institution: | aDivision of Infectious Diseases, SUNY Downstate Medical Center, Brooklyn, New York, USA;bThe Dr. James J. Rahal Jr. Division of Infectious Diseases, New York Hospital Queens, Flushing, New York, USA |
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| Abstract: | Eravacycline demonstrated in vitro activity against a contemporary collection of more than 4,000 Gram-negative pathogens from New York City hospitals, with MIC50/MIC90 values, respectively, for Escherichia coli of 0.12/0.5 μg/ml, Klebsiella pneumoniae of 0.25/1 μg/ml, Enterobacter aerogenes of 0.25/1 μg/ml, Enterobacter cloacae 0.5/1 μg/ml, and Acinetobacter baumannii of 0.5/1 μg/ml. Activity was retained against multidrug-resistant isolates, including those expressing KPC and OXA carbapenemases. For A. baumannii, eravacycline MICs correlated with increased expression of the adeB gene. |
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