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Cooperation between Constitutive and Inducible Chemokines Enables T Cell Engraftment and Immune Attack in Solid Tumors
Affiliation:1. Ludwig Institute for Cancer Research and Department of Oncology, University of Lausanne, Lausanne 1066, Switzerland;2. SIB Swiss Institute of Bioinformatics, Lausanne 1015, Switzerland;3. Ovarian Cancer Research Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA;4. University of Chicago, Knapp Center for Biomedical Discovery, Department of Hematology & Oncology, Chicago, IL 60637, USA;5. Division of Cell and Gene Therapy, OTAT/CBER/FDA, Silver Spring, MD 20993, USA;6. Russ College of Engineering and Technology, Ohio University, Athens, OH 45701, USA;7. Department of Immunology and Gynecologic Oncology, Moffitt Cancer Center, Tampa, FL 33612, USA;8. International Microbiome Centre, University of Calgary, Calgary, AB, Canada;9. Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA;10. Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA;11. Bristol-Myers Squibb, Princeton, NJ 08540, USA;12. Laura and Isaac Perlmutter Cancer Center, New York University, 522 First Avenue, Room 1310 Smilow Building, New York, NY 10016, USA;13. Department of Pathology, Brigham & Women''s Hospital, Boston, MA 02215, USA;14. Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA;15. 2nd Department of Pathology, Attikon University Hospital, National and Kapodistrian University of Athens, Athens 12464, Greece
Abstract:
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  • Keywords:TILs (tumor-infiltrating lymphocytes)  T cell trafficking in the tumor  inducible and constitutive chemokines  CCL5  CXCL9  epigenetic silencing  immunoreactive tumors  checkpoint blockade  IFN-γ  CXCL10
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