Transjugular Intrahepatic Portosystemic Shunt does not affect the efficacy and safety of direct-acting antivirals in patients with advanced cirrhosis: A real-life,case-control study |
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Affiliation: | 1. Department of Experimental and Clinical Medicine, University of Florence, Italy;2. Division of Gastroenterology, Modena Hospital, University of Modena and Reggio Emilia, Modena, Italy;3. Department of Medical and Surgical Sciences, Center for Study and Research on Chronic Hepatitis, University of Bologna, Italy;4. Department of Medical Sciences, Division of Gastroenterology and Hepatology, Molinette Hospital, Turin, Italy;5. Department of Interventional Radiology, Careggi Hospital, Florence, Italy;6. Research Center Denothe, University of Florence, Italy |
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Abstract: | BackgroundTransjugular Intrahepatic Portosystemic Shunt (TIPS) is a well-established treatment for complications of portal hypertension.AimsTo analyze the impact of TIPS on virologic response and safety profile in patients treated with direct-acting antivirals (DAAs).MethodsWe analyzed data from HCV-positive cirrhotic patients treated with DAAs. Twenty-one patients with previous TIPS placement were compared with 42 matched subjects without TIPS. Logistic regression was used to identify predictors of hepatic function worsening and adverse events.ResultsNo differences were found between the two groups in particular regarding sustained virologic response (92.5 and 97.6% in TIPS vs no-TIPS, p = 0.559). Model for End-stage Liver Disease (MELD) of both TIPS and no-TIPS groups declined from baseline to week 24 of follow-up (from 12.5 ± 3.5 to 10.8 ± 3.4 and from 11.1 ± 3.5 to 10.3 ± 3.4, p = 0.044 and 0.025). There were no differences in adverse event rates. At univariate analysis, age was associated with MELD increase from baseline to week 24 (OR 1.111, 95% CI 1.019-1.211, p = 0.017), and patients with higher baseline MELD developed serious adverse events more frequently (OR 0.815, 95% CI 0.658–1.010, p = 0.062). Patients with or without TIPS did not show differences in transplant-free survival.ConclusionTIPS placement does not affect virologic response and clinical outcome of patients receiving DAAs. |
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Keywords: | Advanced liver disease Antiviral therapy Cirrhosis complications Portal hypertension |
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